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Biomaterials Science Vol - 3 Issue - 5

Biomaterials Science Vol - 3 Issue - 4

Biomaterials Science Vol - 3 Issue - 3

Biomaterials Science Vol - 3 Issue - 2

Biomaterials Science Vol -2

Biomaterials Science Vol -1

Development of silica-containing redox nanoparticles for medical applications

Content Provider	Royal Society of Chemistry (RSC)
Author	Nagasaki, Yukio Yoshitomi, Toru
Copyright Year	2015
Abstract	Silica-containing redox nanoparticles (siRNP) are nanocomposites consisting of silica nanoparticles and amphiphilic block copolymers with nitroxide radicals as reactive oxygen species (ROS) scavengers. Electrostatic interactions between the cationic segment of a polymer in the core and the entrapped silica nanoparticles form a crosslinking structure that provides siRNP stability in vivo, even under harsh conditions in the gastrointestinal tract. Due to the adsorption character of silica nanoparticles in the nanocomposite, siRNP can be applied not only for adsorbents of body wastes but also for drug carriers with high loading capacity. The ROS-scavenging character of siRNP significantly improves their performance for medical applications. Here, we describe the development of siRNP and provide two examples of their medical applications as (1) novel nano-sized adsorbents for peritoneal dialysis, and (2) orally administrable drug carriers for the treatment of gastrointestinal inflammation.
Starting Page	810
Ending Page	815
Page Count	6
File Format	HTM / HTML PDF
ISSN	20474830
Volume Number	3
Issue Number	6
Journal	Biomaterials Science
DOI	10.1039/c5bm00057b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Reactive oxygen species Adsorption Redox Amphiphile Polymer Gastrointestinal tract Nanocomposite Dialysis Inflammation Silicon dioxide Aminoxyl group
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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