NDLI: PARAFAC based methods for the analysis of Diltiazem drug excitation emission matrices of fluorescence obtained by a derivatization reaction

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Analytical Methods Vol - 3 Issue - 9

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Analytical Methods Vol -2

Analytical Methods Vol -1

PARAFAC based methods for the analysis of Diltiazem drug excitation emission matrices of fluorescence obtained by a derivatization reaction

Content Provider	Royal Society of Chemistry (RSC)
Author	Silva, Joaquim C. G. Esteves da Leitão, João M. M. Simões, Eliana F. C.
Copyright Year	2011
Abstract	A fluorescent derivatization reaction for Diltiazem drug quantification based on the condensation reaction of citric or malonic acid with acetic anhydride, catalyzed by the tertiary amine group of Diltiazem, was developed. Excitation emission matrices (EEMs) of fluorescence of the pure solvent (ethanol), standard and sample solutions following a standard addition methodology were analysed by PARAFAC based methods (PARAFAC, PARAFAC2 and PARALIND) to obtain robust calibration methodologies. The quantification results of the sample were compared with the official US Pharmacopeia high performance liquid chromatography-ultraviolet method (USP HPLC-UV). Although the experimental sets of EEM show linearity deviations all the PARAFAC based methods allow correct robust estimation of Diltiazem concentration in pharmaceutical formulations. The closest results were: derivatization with citric acid and PARAFAC2 six components non-negativity constraint model with a detection limit of 0.088 ppm; and, derivatization with malonic acid and PARAFAC six components non-negativity constraint model with a detection limit of 0.066 ppm for the malonic acid was observed. The simultaneous utilization of the three PARAFAC methods gives further information about the intrinsic structure of the data sets under analysis, i.e., it works as an efficient diagnostic tool for the existence of non-linearity and colinearity.
Starting Page	2758
Ending Page	2769
Page Count	12
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	3
Issue Number	12
Journal	Analytical Methods
DOI	10.1039/c1ay05560g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Robust statistics Tensor rank decomposition US Pharmacopeia Acid Condensation reaction Ethanol Fluorescence Diltiazem United States Pharmacopeia Acetic anhydride USP Amine Solvent
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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