NDLI: Let there be chip—towards rapid prototyping of microfluidic devices: one-step manufacturing processes

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Analytical Methods Vol - 3 Issue - 9

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Analytical Methods Vol -2

Analytical Methods Vol -1

Let there be chip—towards rapid prototyping of microfluidic devices: one-step manufacturing processes

Content Provider	Royal Society of Chemistry (RSC)
Author	Rapp, Holger Rapp, Bastian E. Waldbaur, Ansgar Länge, Kerstin
Copyright Year	2011
Abstract	Microfluidics is an evolving scientific field with immense commercial potential: analytical applications, such as biochemical assay development, biochemical analysis and biosensors as well as chemical synthesis applications essentially require microfluidics for sample handling, treatment or readout. A number of techniques are available to create microfluidic structures today. On industrial scale replication techniques such as injection molding are the gold standard whereas academic research mostly focuses on replication by casting of soft elastomers such as polydimethylsiloxane (PDMS). Both of these techniques require the creation of a replication master thus creating the microfluidic structure only in the second process step—they can therefore be termed two-(or multi-)step manufacturing techniques. However, very often the number of pieces to be created of one specific microfluidic design is low, sometimes even as low as one. This raises the question if two-step manufacturing is an appropriate choice, particularly if short concept-to-chip times are required. In this case one-step manufacturing techniques that allow the direct creation of microfluidic structures from digital three-dimensional models are preferable. For these processes the number of parts per design is low (sometimes as low as one), but quick adaptation is possible by simply changing digital data. Suitable techniques include, among others, maskless or mask based stereolithography, fused deposition molding and 3D printing. This work intends to discuss the potential and application examples of such processes with a detailed view on applicable materials. It will also point out the advantages and the disadvantages of the respective technique. Furthermore this paper also includes a discussion about non-conventional manufacturing equipment and community projects that can be used in the production of microfluidic devices.
Starting Page	2681
Ending Page	2716
Page Count	36
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	3
Issue Number	12
Journal	Analytical Methods
DOI	10.1039/c1ay05253e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Injection moulding Stereolithography Polydimethylsiloxane Microfluidics 3D printing
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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Let there be chip—towards rapid prototyping of microfluidic devices: one-step manufacturing processes

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Let there be chip—towards rapid prototyping of microfluidic devices: one-step manufacturing processes

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