NDLI: Development of a screening method for the detection of analogues of sildenafil and vardenafil by the use of liquid chromatograph coupled with triple quadrupole linear ion trap mass spectrometer

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Analytical Methods Vol - 2 Issue - 6

Analytical Methods Vol - 2 Issue - 5

Analytical Methods Vol - 2 Issue - 4

Analytical Methods Vol - 2 Issue - 3

Analytical Methods Vol - 2 Issue - 2

Analytical Methods Vol -1

Development of a screening method for the detection of analogues of sildenafil and vardenafil by the use of liquid chromatograph coupled with triple quadrupole linear ion trap mass spectrometer

Content Provider	Royal Society of Chemistry (RSC)
Author	Choi, Koon Kay Ng, Chi Shing Ng, Ping Chung Law, Tin Yau Cheung, Yuk King
Copyright Year	2010
Abstract	Sildenafil and vardenafil are western drugs used in the treatment of male erectile dysfunction (ED). Prescription is required to use these drugs in many countries including Hong Kong. Recently, health supplements and Chinese herbal drugs claiming to have improvement in male potency were found to be adulterated with these drugs. Even worse, some of these products were found to contain analogues of ED drugs. For regulatory purposes, drug enforcement agencies often use analytical techniques such as HPLC-UV or LC-MS/MS in scheduled multiple reaction monitoring (MRM) mode for routine screening of western drug ingredients. However, drug analogues are expected to have different elution profiles and the ions produced by drug analogues would be different, making them transparent in scheduled MRM conditions. To tackle the problem, an acquisition method that combined precursor ion scan (PIS) with information dependent acquisition (IDA) followed by enhanced product ion (EPI) scan was developed. Results suggested that such an approach could provide a very powerful tool in the detection of analogues of sildenafil and vardenafil.
Starting Page	890
Ending Page	896
Page Count	7
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	2
Issue Number	7
Journal	Analytical Methods
DOI	10.1039/b9ay00112c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Even Worse Hong Kong Ion Vardenafil Erectile dysfunction Sildenafil EPI
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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