NDLI: An efficient, sensitive and accurate method for the detection of astragaloside IV in Chinese functional spirit by ultra-performance liquid chromatography

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An efficient, sensitive and accurate method for the detection of astragaloside IV in Chinese functional spirit by ultra-performance liquid chromatography–quadrupole-orbitrap mass spectrometry

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An efficient, sensitive and accurate method for the detection of astragaloside IV in Chinese functional spirit by ultra-performance liquid chromatography–quadrupole-orbitrap mass spectrometry

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Li Yu, Xinyu Wu, Xinyue Zhang, Zhan Zhao, Hongyan Zhou, Xinhu Li, Lei Chen, Xiang
Copyright Year	2015
Abstract	Mainly consisting of Chinese white spirit and traditional Chinese medicine, Chinese functional spirit is a popular health food in China due to its healthy effects, such as resisting fatigue and enhancing immunity. As one of the major active constituents of Radix Astragali, astragaloside-IV (AGS-IV) commonly exists in Chinese functional spirit. However, the concentration of AGS-IV in this health food is still rarely known. We firstly report an efficient, sensitive and accurate analytical method based on ultra-performance liquid chromatography (UPLC) coupled with quadrupole-orbitrap mass spectrometry (Q Exactive MS) to determine AGS-IV in Chinese functional spirit. Conditions of UPLC and Q Exactive MS were optimized. Sample pre-treatment was done by diluting ten times to weaken the matrix effect. The limit of quantitation and the limit of detection were 0.5 and 0.25 ng mL−1, respectively. The recovery was 92.5–96.7% and the relative standard deviation was 0.8–1.6%. The regression coefficient was 0.9999. In both the selected brands, AGS-IV was at trace levels (76.7 and 59.8 ng mL−1, respectively), which is nearly thousands of times lower than in traditional Chinese medicine extracts. From this analysis method, AGS-IV in Chinese functional spirit for daily health improvement could be clearly determined, and meanwhile it could promote a more scientific and reasonable quality control of Chinese functional spirit rather than detecting the content of total saponins to represent all the efficacy components in it.
Starting Page	10199
Ending Page	10206
Page Count	8
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	7
Issue Number	24
Journal	Analytical Methods
DOI	10.1039/c5ay02809d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	UPLC Linear regression China Traditional Chinese medicine Positive-definite matrix Zinc oxide High-performance liquid chromatography Mass spectrometry Coefficient of variation Immune system
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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