NDLI: Analysis of dialkyl urine metabolites of organophosphate pesticides by a liquid chromatography mass spectrometry technique

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Analysis of dialkyl urine metabolites of organophosphate pesticides by a liquid chromatography mass spectrometry technique

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Analytical Methods Vol - 6 Issue - 5

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Analysis of dialkyl urine metabolites of organophosphate pesticides by a liquid chromatography mass spectrometry technique

Content Provider	Royal Society of Chemistry (RSC)
Author	Bhatnagar, Vijay Ahmed, M. Noor Vasudev, Kasturi Kumari, Alka Rao, M. Vishnu Vardhana Reddy, B. Venkat Sinha, Sukesh Narayan Ashu, Shaik
Copyright Year	2014
Abstract	A sensitive method for the quantification of six dialkyl phosphate (DAP) urinary metabolites (DMP, DEP, DMTP, DETP, DMDTP, and DEDTP) in urine samples at ng mL−1 concentrations was developed. A solvent extraction followed by selective analysis by a liquid chromatography-mass spectrometric method was used. This method was found to be very accurate and exhibited the limits of detection as follows: DMP, 0.058 ng mL−1; DEP, 0.009 ng mL−1; DMTP, 0.004 ng mL−1; DETP, 0.0148 ng mL−1; DMDTP, 0.00861 ng mL−1; and DEDTP, 0.0198 ng mL−1. The limits of quantification were in the range of 0.0287 ng mL−1 to 0.0743 ng mL−1. The value of the coefficient was found to be ≥0.999 for all of the metabolites. The percent recovery of the pesticides, at the lowest levels of detection, ranged from 93–107% and the coefficient variation was found in the range of 0.400–7.98, which indicates high degree of accuracy and precision. This method is found to be more cost-effective because the quantity of chemicals involved is much less compared with other methods. This method is also found to be simple because the number of steps where there was a chance of sample spillage were reduced, and it can also be used for quantification of pesticide concentrations in urine samples collected from the general population throughout various parts of the world. Initially, 30 samples were analyzed, and the mean concentration of the metabolites ranged from 0.058 to 118.27 ng mL−1, which suggests that the children of Hyderabad city were exposed to OP pesticides.
Starting Page	1825
Ending Page	1834
Page Count	10
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	6
Issue Number	6
Journal	Analytical Methods
DOI	10.1039/c3ay41958d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Urine Dublin Metropolitan Police Pesticide Phosphate Liquid\u2013liquid extraction DEP Hyderabad
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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Analysis of dialkyl urine metabolites of organophosphate pesticides by a liquid chromatography mass spectrometry technique

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