NDLI: <i>In situ</i> detection of γ-hydroxybutyrate and γ-butyrolactone in drinks by secondary electrospray ionization

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Analytical Methods Vol - 5 Issue - 3

Analytical Methods Vol -4

Analytical Methods Vol -3

Analytical Methods Vol -2

Analytical Methods Vol -1

In situ detection of γ-hydroxybutyrate and γ-butyrolactone in drinks by secondary electrospray ionization

Content Provider	Royal Society of Chemistry (RSC)
Author	Meier, Lukas Berchtold, Christian Schmid, Stefan Zenobi, Renato
Copyright Year	2013
Abstract	γ-Hydroxybutyrate (GHB) and γ-butyrolactone (GBL) are used as “date rape drugs” since they cause catalepsy and memory loss. A new application of secondary electrospray ionization (SESI) mass spectrometry for in situ detection of GHB and GBL in drinks and body fluids is introduced. Different mass spectrometers were compared, including a portable, miniaturized ion trap, a semi mobile bench-top ion trap, and a quadrupole time-of-flight instrument. Direct ionization of GHB and GBL from the headspace of drinks was shown, and the suitability for on-site measurements was tested. Several matrices including various drinks as well as body fluids such as urine and saliva were analyzed. SESI provides a robust, reliable, fast, and efficient ionization method, which is largely independent of the mass spectrometer and the matrix used. The detection limits for GHB and GBL in drinks were found to be always below 0.5 g L−1, which is sufficient to identify them in beverages (a dose of about 2 g L−1 is commonly used). 8 mg L−1 GHB were detectable in urine, which suffices to identify an intoxicated individual. Overall, GHB and GBL can be detected in drinks and small leftovers of drinks as well as in body fluids at concentration levels that are of practical relevance. With a mobile MS instrument, this method could be applied as a diagnostic as well as a preventive on-site method.
Starting Page	844
Ending Page	850
Page Count	7
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	5
Issue Number	4
Journal	Analytical Methods
DOI	10.1039/c2ay26009c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Urine Rape Memory Electrospray ionization Catalepsy Ion Time-of-flight mass spectrometry SESI GBL Gamma-Hydroxybutyric acid Quadrupole mass analyzer Ionization Gamma-Butyrolactone Extracellular matrix Mass spectrometry Saliva
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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