NDLI: Applications of a confined DART (direct analysis in real time) ion source for online <i>in vivo</i> analysis of human breath

Please wait, while we are loading the content...

Dual-aptamer-based sensitive and selective detection of prion protein through the fluorescence resonance energy transfer between quantum dots and graphene oxide

Room temperature phosphorescence of the 1-bromonaphthalene/β-cyclodextrin inclusion complex: comparison between right-angle and front-face illumination geometry

Assessing melatonin and its oxidative metabolites amounts in biological fluid and culture medium by liquid chromatography electrospray ionization tandem mass spectrometry (LC–ESI-MS/MS)

Hydrophilic interaction/cation-exchange chromatography for glycopeptide enrichment by using a modified strong-cation exchange material

Investigation of blood vessels in glioblastoma at a micrometric scale: a comparative study by synchrotron and conventional micro-FTIR

Applications of a confined DART (direct analysis in real time) ion source for online in vivo analysis of human breath

Determination of chromium and antimony in polymers from electrical and electronic equipment using high-resolution continuum source graphite furnace atomic absorption spectrometry

Electrochemical response of hydroxyurea by different voltammetric techniques at carbon paste electrode

Extraction of salbutamol using co-sintered molecularly imprinted polymers as a new format of solid-phase extraction

Classification of edible oils using 532 nm laser-induced fluorescence combined with support vector machine

Role of magnetic Fe₃O₄ graphene oxide in chemiluminescent aptasensors capable of sensing tumor markers in human serum

Quantitation of triacylglycerols in vegetable oils and fats by easy ambient sonic-spray ionization mass spectrometry

Microwave-assisted silylation followed by gas chromatography/mass spectrometry for simultaneous quantification of nicotine and its four metabolites in urine

Electrochemical behavior of dopamine at a [1,1′-binaphthalene]-4,4′-diol-modified carbon nanotube paste electrode and the simultaneous determination of dopamine, folic acid and uric acid

Forcing immunoassay for sulfonamides to higher sensitivity and broader detection spectrum by site heterologous hapten inducing affinity improvement

Determination of Dechlorane compounds in aqueous samples using ultrasound-assisted dispersive liquid–liquid microextraction and gas chromatography-electron-capture negative ion-mass spectrometry

Development of supercritical fluid (carbon dioxide) based ultra performance convergence chromatographic stability indicating assay method for the determination of clofarabine in injection

A sensitive LC-ESI-MS/MS method for the quantification of low concentrations of buspirone in human plasma

A novel nanomachined flow channel glucose sensor based on an alumina membrane

Optimization of two-dimensional gel electrophoresis for proteome analysis of suspension-cultured ginseng cells

Investigation of interaction between bovine serum albumin and drugs by fluorescence spectrometry

LC-MS/MS quantification of salvinorin A from biological fluids

Size-controllable preparation of palladium nanoparticles assembled on TiO₂/graphene nanosheets and their electrocatalytic activity for glucose biosensing

Holistic analysis of seven constituents from five medicinal herbs composing Wuhu powders in a single run by ultra performance liquid chromatography: application to quality control study

Polypyrrole nanotubes for electrochemically controlled solid-phase extraction of anions and cations

Retention mechanism and enrichment of glycopeptides on titanium dioxide

Direct analysis in real time ionization/quadrupole time-of-flight tandem mass spectrometry for rapid identification of iridoid glycosides and caffeoylquinic acids in Re Du Ning Injections

Electro-reduced graphene oxide film modified glassy carbon electrode as an electrochemical sensor for sibutramine

Application of sol–gel based molecularly imprinted xerogel for on-line capillary microextraction of fentanyl from urine and plasma samples

Simultaneous determination of three strobilurin fungicide residues in fruits, vegetables and soil by a modified quick, easy, cheap, effective, rugged (QuEChERS) method coupled with gas chromatography-tandem mass spectrometry

Incorporation of high performance liquid chromatography with resonance Rayleigh scattering detection for determination of procaine and lidocaine in human plasma

Quantitative determination of platinum derived from cisplatin in human plasma ultrafiltrate using derivatization with diethyldithiocarbamate and liquid chromatography coupled with electrospray ionization tandem mass spectrometry

Acid extraction for the determination of methyl mercury in biotissues by isotope dilution gas chromatography inductively coupled plasma-mass spectrometry

Back matter

Back cover

Analytical Methods Vol - 5 Issue - 19

Analytical Methods Vol - 5 Issue - 9

Analytical Methods Vol - 5 Issue - 8

Analytical Methods Vol - 5 Issue - 7

Analytical Methods Vol - 5 Issue - 6

Analytical Methods Vol - 5 Issue - 5

Analytical Methods Vol - 5 Issue - 4

Analytical Methods Vol - 5 Issue - 3

Analytical Methods Vol -4

Analytical Methods Vol -3

Analytical Methods Vol -2

Analytical Methods Vol -1

Applications of a confined DART (direct analysis in real time) ion source for online in vivo analysis of human breath

Content Provider	Royal Society of Chemistry (RSC)
Author	Li, Yue
Copyright Year	2013
Abstract	Human breath is composed of many volatile metabolites that can potentially provide information about a person's health status. A sensitive assay to identify these volatile organic compounds as biomarkers is ideal and important for early detection of many diseases. However, the diagnosis through online breath analysis based on mass spectrometry is difficult due to the low concentration of pertinent compounds in breath. The DART (direct analysis in real time) ion source is a novel atmospheric pressure ionization technique, which can efficiently ionize gaseous, liquid and solid samples with high throughput. A major problem in analysis of gaseous samples is its poor detection sensitivity due to open-air sampling. Recently, a confined DART ion source (cDART) was developed, where the plasma generated by the atmospheric pressure glow discharge ionizes gas-phase molecules in a Tee-shaped flow tube instead of open air. It leads to a significant increase of the ionization efficiency of gaseous samples. In this study, the cDART source was modified and applied in online analysis of exhaled breath. The limit of detection of the improved cDART source was determined to be at the level of low ppb. The cDART source was used in the real-time monitoring of an oral anesthetic drug. The concentration variations of two active ingredients in exhaled breath, menthol and benzocaine, and their metabolites with time were obtained. The results show that the cDART ion source is a powerful analytical tool to provide high sensitivity and high throughput analysis for volatile organic compounds in human breath, and can find potential applications in clinical diagnosis and therapy.
Starting Page	6933
Ending Page	6940
Page Count	8
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	5
Issue Number	24
Journal	Analytical Methods
DOI	10.1039/c3ay41406j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	DART DART ion source Benzocaine Atmospheric pressure Anesthetic Ionization Ion source Glow discharge Volatile organic compound Menthol Mass spectrometry Blood plasma
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Direct analysis in real time mass spectrometry of fused ring heterocyclic organometallic compounds

Analysis of soils by glow discharge mass spectrometry

Ion formation at the boundary between a fast flow glow discharge ion source and a quadrupole mass spectrometer

Ionization characteristics of glycosides by direct analysis in real time quadrupole-time of flight mass spectrometry

Understanding the Flowing Atmospheric-Pressure Afterglow (FAPA) Ambient Ionization Source through Optical Means

Atmospheric sampling glow discharge ionization source

Atmospheric Pressure Dark-Current Argon Discharge Ionization with Comparable Performance to Direct Analysis in Real Time Mass Spectrometry.

Understanding the Flowing Atmospheric-Pressure Afterglow (FAPA) Ambient Ionization Source through Optical Means

Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis

Applications of a confined DART (direct analysis in real time) ion source for online in vivo analysis of human breath

Similar Documents

Direct analysis in real time mass spectrometry of fused ring heterocyclic organometallic compounds

Analysis of soils by glow discharge mass spectrometry

Ion formation at the boundary between a fast flow glow discharge ion source and a quadrupole mass spectrometer

Ionization characteristics of glycosides by direct analysis in real time quadrupole-time of flight mass spectrometry

Understanding the Flowing Atmospheric-Pressure Afterglow (FAPA) Ambient Ionization Source through Optical Means

Atmospheric sampling glow discharge ionization source

Atmospheric Pressure Dark-Current Argon Discharge Ionization with Comparable Performance to Direct Analysis in Real Time Mass Spectrometry.

Understanding the Flowing Atmospheric-Pressure Afterglow (FAPA) Ambient Ionization Source through Optical Means

Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis

Applications of a confined DART (direct analysis in real time) ion source for online in vivo analysis of human breath