NDLI: Electrochemical response of hydroxyurea by different voltammetric techniques at carbon paste electrode

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Analytical Methods Vol - 5 Issue - 19

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Electrochemical response of hydroxyurea by different voltammetric techniques at carbon paste electrode

Content Provider	Royal Society of Chemistry (RSC)
Author	Nandibewoor, Sharanappa T. Alagur, Manjunath M. Naik, Keerti M.
Copyright Year	2013
Abstract	A simple and novel electroanalysis of hydroxyurea (HU) drug at carbon paste electrode has been investigated for the first time using cyclic, linear sweep and differential pulse voltammetric techniques. The oxidation of HU is irreversible and exhibits a diffusion controlled process and is pH dependent. The oxidation mechanism is proposed. The dependence of the current on pH, the concentration, nature of buffer, and scan rate is investigated to optimize the experimental conditions for the determination of HU. It was found that the optimum buffer for the determination of HU was pH 7.0, a physiological pH. In the range of 0.2 to 1.0 mM, the current measured by differential pulse voltammetry presents a good linear property as a function of the concentration of HU with a limit of detection of 6.52 μM. In addition, reproducibility, precision and accuracy of the method were checked as well. The developed method was successfully applied to HU determination in pharmaceutical formulation and human urine. The method finds its applications in quality control laboratories and pharmacokinetics.
Starting Page	6947
Ending Page	6953
Page Count	7
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	5
Issue Number	24
Journal	Analytical Methods
DOI	10.1039/c3ay41680a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Urine Hydroxycarbamide Dependent and independent variables PH Pharmaceutical formulation Carbon paste electrode Diffusion Pharmacokinetics Differential pulse voltammetry
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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