NDLI: Graphitized mesoporous carbon modified glassy carbon electrode for selective sensing of xanthine, hypoxanthine and uric acid

Content Provider	Royal Society of Chemistry (RSC)
Author	Kumar, Annamalai Senthil Thangaraj, Rajendiran
Copyright Year	2012
Abstract	An efficient electrochemical sensor for simultaneous electrochemical sensing of three purine compounds, uric acid (UA), xanthine (X) and hypoxanthine (HX), using a graphitized mesoporous carbon (GMC) modified glassy carbon electrode (GCE/GMC) has been demonstrated in pH 7 phosphate buffer solution without any enzyme, prior to electrode activation, surfactant and sample pre-concentration step. Electrochemical investigation of the GCE/GMC with [Fe(CN)6]3− indicates metallic conductor like surface features of the modified electrode. A diffusion controlled reaction mechanism was identified for the electro-oxidation of the three purine compounds with an electrocatalytic pathway, except for the UA, where it shows a surface area effect with a mixed-diffusion and adsorption controlled mechanism at higher scan rates (>70 mV s−1). Calculated full-width of the half maximum values for the simultaneous detection of the three purine compounds are 42, 53 and 64 mV respectively and these are the lowest values ever reported in the literature, suggesting effective electron-transfer behaviour of the modified electrode for the purine oxidations. Calibration plots for the simultaneous detection of the purine compounds were linear in the concentration range of 20–400 μM, 20–320 μM and 20–240 μM for UA, X and HX with detection limit values of 110 nM, 388 nM, and 351 nM respectively. Selective sensing of the purine compounds in human blood-plasma, urine and fish samples was successfully demonstrated with recovery values ∼100%.
Starting Page	2162
Ending Page	2171
Page Count	10
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	4
Issue Number	7
Journal	Analytical Methods
DOI	10.1039/c2ay25029b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Urine Acid Electrode Molecular cloud Enzyme Urban area Xanthine UA Buffer solution Surfactant Carbon Mesoporous material Adsorption Phosphate Electrochemistry PH Reaction mechanism Hypoxanthine Ferricyanide Purine Diffusion
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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