NDLI: Drastic Reduction of a Filarial Infection in Eosinophilic Interleukin-5 Transgenic Mice

Content Provider	PubMed Central
Author	Martin, Coralie Goff, Laëtitia Le Ungeheuer, Marie-noelle Vuong, Phat N. Bain, Odile
Editor	Petri, W. A.
Copyright Year	2000
Abstract	In order to establish the role of eosinophils in destroying parasites, transgenic mice have been used in experimental helminthiases but not in filariasis. Litomosoides sigmodontis offers a good opportunity for this study because it is the only filarial species that completes its life cycle in mice. Its development was compared in transgenic CBA/Ca mice overexpressing interleukin-5 (IL-5) and in wild-type mice following subcutaneous inoculation of 40 infective larvae. An acceleration of larval growth was observed in the IL-5 transgenic mice. However, the recovery rate of adult worms was considerably reduced in these mice, as evidenced 2 months postinoculation (p.i.). The reduction occurs between days 10 and 30 p.i. in the coelomic cavities. As early as day 10, spherical aggregates of eosinophils and macrophages are seen attached on live developing larvae (always similarly localized on the worm) in both wild-type and transgenic mice. However, on day 60 p.i., granulomas were found in the transgenic mice only, probably because of the higher density of eosinophils. Furthermore, on day 30 p.i., young filariae are seen trapped in granulomas, some of them surrounded by Splendore-Hoeppli deposits, which illustrates the release of the major basic protein by eosinophils. The high protection rate obtained (65%) is similar to that observed previously in BALB/c mice following vaccination with irradiated larvae. Both protocols have a common factor, the high production of IL-5 and eosinophilia. However, protection occurs later in primary infected transgenic mice because specific antibodies are not yet present at the time of challenge.
Starting Page	3651
File Format	PDF
ISSN	10985522
e-ISSN	10985522
Journal	Infection and Immunity
Issue Number	6
Volume Number	68
Language	English
Publisher	American Society for Microbiology
Publisher Date	2000-06-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology Immunology Microbiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

NK T Cells Are a Source of Early Interleukin-4 following Infection with Third-Stage Larvae of the Filarial Nematode Brugia pahangi

Interleukin-5 transgenic mice show augmented resistance to Angiostrongylus costaricensis infection

Counter-Protective Role for Interleukin-5 during Acute Toxoplasma gondii Infection

Interleukin-5 Is Essential for Vaccine-Mediated Immunity but Not Innate Resistance to a Filarial Parasite

Interleukin-17-Mediated Control of Parasitemia in Experimental Trypanosoma congolense Infection in Mice▿

Mice Genetically Deficient in Immunoglobulin E Are More Permissive Hosts than Wild-Type Mice to a Primary, but Not Secondary, Infection with the Filarial Nematode Brugia malayi

Development of a Recombinant Antigen Vaccine against Infection with the Filarial Worm Onchocerca volvulus

Trapping and Immobilization of Nippostrongylus brasiliensis Larvae at the Site of Inoculation in Primary Infections of Interleukin-5 Transgenic Mice

5-Lipoxygenase Negatively Regulates Th1 Response during Brucella abortus Infection in Mice

Drastic Reduction of a Filarial Infection in Eosinophilic Interleukin-5 Transgenic Mice

Similar Documents

NK T Cells Are a Source of Early Interleukin-4 following Infection with Third-Stage Larvae of the Filarial Nematode Brugia pahangi

Interleukin-5 transgenic mice show augmented resistance to Angiostrongylus costaricensis infection

Counter-Protective Role for Interleukin-5 during Acute Toxoplasma gondii Infection

Interleukin-5 Is Essential for Vaccine-Mediated Immunity but Not Innate Resistance to a Filarial Parasite

Interleukin-17-Mediated Control of Parasitemia in Experimental Trypanosoma congolense Infection in Mice▿

Mice Genetically Deficient in Immunoglobulin E Are More Permissive Hosts than Wild-Type Mice to a Primary, but Not Secondary, Infection with the Filarial Nematode Brugia malayi

Development of a Recombinant Antigen Vaccine against Infection with the Filarial Worm Onchocerca volvulus

Trapping and Immobilization of Nippostrongylus brasiliensis Larvae at the Site of Inoculation in Primary Infections of Interleukin-5 Transgenic Mice

5-Lipoxygenase Negatively Regulates Th1 Response during Brucella abortus Infection in Mice

Drastic Reduction of a Filarial Infection in Eosinophilic Interleukin-5 Transgenic Mice