NDLI: Thyroperoxidase, an auto-antigen with a mosaic structure made of nuclear and mitochondrial gene modules.

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Thyroperoxidase, an auto-antigen with a mosaic structure made of nuclear and mitochondrial gene modules.

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Thyroperoxidase, an auto-antigen with a mosaic structure made of nuclear and mitochondrial gene modules.

Content Provider	PubMed Central
Author	Libert, F. Ruel, J. Ludgate, M. Swillens, S. Alexander, N. Vassart, G. Dinsart, C.
Abstract	A lambda gt11 cDNA library was constructed from a normal human thyroid and screened with a rabbit anti-porcine thyroperoxidase antibody. A series of thyroperoxidase (TPO) clones were obtained which allowed determination of the complete primary structure of the protein. The library was also screened with serum from a patient with Hashimoto's thyroiditis, an autoimmune disease characterized by the presence in the serum of high titers of autoantibodies directed against the 'microsomal antigen' (McAg). Comparison of the cDNA sequences from TPO clones and McAg clones provides definite proof that the McAg is TPO. A short segment of TPO was characterized as bearing a major epitope involved in autoimmunity. The primary structure of TPO was 42% homologous to myeloperoxidase (MPO). It contains, in addition, a C-terminal extension with a membrane anchor region contiguous to two domains encoded by modules belonging to the EGF and C4b gene families. The existence in TPO of still another domain presenting a significant homology with a putative heme-binding region of cytochrome C oxidase polypeptide I raises the possibility that a mitochondrial gene module has contributed a piece to the evolution of a typical nuclear mosaic gene.
Starting Page	4193
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	13
Volume Number	6
Language	English
Publisher Date	1987-12-20
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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