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| Content Provider | PubMed Central |
|---|---|
| Author | Ly, K. Ina Crew, Laura L. Graham, Carrie A. Mrugala, Maciej M. |
| Copyright Year | 2016 |
| Abstract | Rituximab (RTX) improves the outcome in patients with systemic diffuse large B-cell lymphoma (DLBCL), but its benefit in primary central nervous system lymphoma (PCNSL) is unclear. In the present study, a single-institution retrospective analysis was performed for 12 patients with newly diagnosed PCNSL treated with combined high-dose methotrexate (HD-MTX) and RTX. MTX was administered biweekly at 8 g/m2/dose until a complete response (CR) was achieved or for a maximum of eight doses. RTX was provided for a total of eight weekly doses at 375 mg/m2/dose. Following a median of 11 cycles of MTX, the radiographic overall response rate was 91% and the CR rate was 58%. A CR was achieved after a median 6 cycles of MTX. The median progression-free survival time was 22 months and the median overall survival time has not yet been attained. These results compare favorably to single-agent HD-MTX and suggest a role for immunochemotherapy in the treatment of PCNSL. |
| Related Links | http://dx.doi.org/10.3892/ol.2016.4393 |
| Starting Page | 3471 |
| File Format | |
| ISSN | 17921082 |
| e-ISSN | 17921082 |
| Journal | Oncology Letters |
| Issue Number | 5 |
| Volume Number | 11 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2016-05-01 |
| Access Restriction | Open |
| Rights Holder | D.A. Spandidos |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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