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A paradoxical relationship between Resveratrol and copper (II) with respect to degradation of DNA and RNA
| Content Provider | PubMed Central |
|---|---|
| Author | Subramaniam, Siddharth Vohra, Iqbal Iyer, Aishwarya Nair, Naveen K. Mittra, Indraneel |
| Copyright Year | 2016 |
| Abstract | Resveratrol (R), a plant polyphenol, is known to reduce Cu (II) to Cu (I) generating reactive oxygen species that can cleave plasmid DNA. Here we report a surprising observation of a paradoxical relationship between R and Cu whereby plasmid DNA cleaving / degrading activity of R-Cu increased progressively as the ratio of R to Cu was increased i.e., the concentration of Cu was successively reduced with respect to a fixed concentration R. Whereas cleavage of plasmid DNA occurred at low molar ratios of R to Cu, at higher ratios, complete degradation of DNA was achieved. By further increasing the ratio, whereby the concentration of Cu was reduced to very low levels, the DNA degrading activity of R-Cu was lost. This paradoxical relationship is also seen with respect to eukaryotic genomic DNA and RNA. Since R-Cu may have anti-cancer and anti-viral activities, our findings may not only help to improve the therapeutic efficacy of R-Cu but also reduce its toxic side effects with the use of low concentration of Cu. |
| Related Links | http://dx.doi.org/10.12688/f1000research.7202.2 |
| Starting Page | 1145 |
| File Format | |
| ISSN | 20461402 |
| e-ISSN | 20461402 |
| Journal | F1000Research |
| Volume Number | 4 |
| Language | English |
| Publisher | F1000Research |
| Access Restriction | Open |
| Rights Holder | F1000Research |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics |
