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Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs: from modeling to clinical use
| Content Provider | PubMed Central |
|---|---|
| Author | Billard, Valerie |
| Copyright Year | 2015 |
| Abstract | Anesthesia is a combination of unconsciousness, amnesia, and analgesia, expressed in sleeping patients by limited reaction to noxious stimulations. It is achieved by several classes of drugs, acting mainly on central nervous system. Compared to other therapeutic families, the anesthetic drugs, administered by intravenous or pulmonary route, are quickly distributed in the blood and induce in a few minutes effects that are fully reversible within minutes or hours. These effects change in parallel with the concentration of the drug, and the concentration time course of the drug follows with a reasonable precision mathematical models based on the Fick principle. |
| Related Links | http://dx.doi.org/10.12688/f1000research.6601.1 |
| File Format | |
| ISSN | 20461402 |
| e-ISSN | 20461402 |
| Journal | F1000Research |
| Volume Number | 4 |
| Language | English |
| Publisher | F1000Research |
| Publisher Date | 2015-11-18 |
| Access Restriction | Open |
| Rights Holder | F1000Research |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics |