NDLI: Optimization of contrast-to-tissue ratio through pulse windowing in dual-frequency “acoustic angiography” imaging

Please wait, while we are loading the content...

Optimization of contrast-to-tissue ratio through pulse windowing in dual-frequency “acoustic angiography” imaging

Content Provider	PubMed Central
Author	Lindsey, Brooks D. Shelton, Sarah E. Dayton, Paul A.
Abstract	Early-stage tumors in many cancers are characterized by vascular remodeling, indicative of transformations in cell function. We have previously presented a high-resolution ultrasound imaging approach for detecting these changes which is based on microbubble contrast agents. In this technique, images are formed from only the higher harmonics of microbubble contrast agents, producing images of vasculature alone with 100–200 μm resolution. In this article, shaped transmit pulses are applied to imaging the higher broadband harmonic echoes of microbubble contrast agents, and the effects of varying pulse window and phasing on microbubble and tissue harmonic echoes are evaluated using a dual-frequency transducer in vitro and in vivo. An increase in contrast-to-tissue ratio of 6.8 ± 2.3 dB was observed in vitro by using an inverted pulse with a cosine window relative to a non-inverted pulse with a rectangular window. The increase in mean image intensity due to contrast enhancement in vivo in five rodents was 13.9 ± 3.0 dB greater for an inverted cosine-windowed pulse and 17.8 ± 3.6 dB greater for a non-inverted Gaussian-windowed relative to a non-inverted pulse with a rectangular window. Implications for pre-clinical and diagnostic imaging are also discussed.
Related Links	http://dx.doi.org/10.1016/j.ultrasmedbio.2015.02.011
Ending Page	1895
Page Count	12
Starting Page	1884
File Format	PDF
ISSN	03015629
e-ISSN	1879291X
Journal	Ultrasound in medicine & biology
Issue Number	7
Volume Number	41
Language	English
Publisher Date	2015-07-01
Access Restriction	Open
Subject Keyword	Biophysics Radiological and Ultrasound Technology Radiology Nuclear Medicine and imaging Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Acoustics and Ultrasonics Biophysics Radiological and Ultrasound Technology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

CONTRAST-ENHANCED INTRAVASCULAR ULTRASOUND PULSE SEQUENCES FOR BANDWIDTH-LIMITED TRANSDUCERS

IMPROVEMENTS IN ELASTOGRAPHIC CONTRAST-TO-NOISE RATIO USING SPATIAL-ANGULAR COMPOUNDING

In Vitro Acoustic Characterization of Three Phospholipid Ultrasound Contrast Agents from 12 to 43 MHz

Rapid 3D Imaging of Contrast Flow: Demonstration of a Dual Beam Technique

Ultrasound phase contrast thermal imaging with reflex transmission imaging methods in tissue phantoms

Design factors of intravascular dual frequency transducers for super-harmonic contrast imaging and acoustic angiography

DUAL-FOCUS THERAPEUTIC ULTRASOUND TRANSDUCER FOR PRODUCTION OF BROAD TISSUE LESIONS

Frequency Dependence of Kidney Injury Induced by Contrast-Aided Diagnostic Ultrasound in Rats

Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption

Optimization of contrast-to-tissue ratio through pulse windowing in dual-frequency “acoustic angiography” imaging

Similar Documents

CONTRAST-ENHANCED INTRAVASCULAR ULTRASOUND PULSE SEQUENCES FOR BANDWIDTH-LIMITED TRANSDUCERS

IMPROVEMENTS IN ELASTOGRAPHIC CONTRAST-TO-NOISE RATIO USING SPATIAL-ANGULAR COMPOUNDING

In Vitro Acoustic Characterization of Three Phospholipid Ultrasound Contrast Agents from 12 to 43 MHz

Rapid 3D Imaging of Contrast Flow: Demonstration of a Dual Beam Technique

Ultrasound phase contrast thermal imaging with reflex transmission imaging methods in tissue phantoms

Design factors of intravascular dual frequency transducers for super-harmonic contrast imaging and acoustic angiography

DUAL-FOCUS THERAPEUTIC ULTRASOUND TRANSDUCER FOR PRODUCTION OF BROAD TISSUE LESIONS

Frequency Dependence of Kidney Injury Induced by Contrast-Aided Diagnostic Ultrasound in Rats

Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption

Optimization of contrast-to-tissue ratio through pulse windowing in dual-frequency “acoustic angiography” imaging