NDLI: Six Serum miRNAs Fail to Validate as Myotonic Dystrophy Type 1 Biomarkers

Content Provider	PubMed Central
Author	Fernandez-costa, Juan M. Llamusi, Beatriz Bargiela, Ariadna Zulaica, Miren Carmen, Alvarez-abril M. Manuel, Perez-alonso Munain, Adolfo Lopez De Arturo, Lopez-castel Artero, Ruben
Editor	Ray, Ratna B.
Copyright Year	2016
Abstract	Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disease caused by expansion of a CTG microsatellite in the 3’ untranslated region of the DMPK gene. Despite characteristic muscular, cardiac, and neuropsychological symptoms, CTG trinucleotide repeats are unstable both in the somatic and germinal lines, making the age of onset, clinical presentation, and disease severity very variable. A molecular biomarker to stratify patients and to follow disease progression is, thus, an unmet medical need. Looking for a novel biomarker, and given that specific miRNAs have been found to be misregulated in DM1 heart and muscle tissues, we profiled the expression of 175 known serum miRNAs in DM1 samples. The differences detected between patients and controls were less than 2.6 fold for all of them and a selection of six candidate miRNAs, miR-103, miR-107, miR-21, miR-29a, miR-30c, and miR-652 all failed to show consistent differences in serum expression in subsequent validation experiments.
Related Links	http://dx.doi.org/10.1371/journal.pone.0150501
Starting Page	150501
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	2
Volume Number	11
Language	English
Publisher	Public Library of Science
Publisher Date	2016-02-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Elevated Muscle-Specific miRNAs in Serum of Myotonic Dystrophy Patients Relate to Muscle Disease Progress

Overexpression of CUGBP1 in Skeletal Muscle from Adult Classic Myotonic Dystrophy Type 1 but Not from Myotonic Dystrophy Type 2

Cell Membrane Integrity in Myotonic Dystrophy Type 1: Implications for Therapy

Reconstructing the Rasch-Built Myotonic Dystrophy Type 1 Activity and Participation Scale

Deregulated MicroRNAs in Myotonic Dystrophy Type 2

Characteristic MRI Findings of upper Limb Muscle Involvement in Myotonic Dystrophy Type 1

RBFOX1 Cooperates with MBNL1 to Control Splicing in Muscle, Including Events Altered in Myotonic Dystrophy Type 1

Serum Cytokines as Biomarkers in Islet Cell Transplantation for Type 1 Diabetes

Overweight Is an Independent Risk Factor for Reduced Lung Volumes in Myotonic Dystrophy Type 1

Six Serum miRNAs Fail to Validate as Myotonic Dystrophy Type 1 Biomarkers

Similar Documents

Elevated Muscle-Specific miRNAs in Serum of Myotonic Dystrophy Patients Relate to Muscle Disease Progress

Overexpression of CUGBP1 in Skeletal Muscle from Adult Classic Myotonic Dystrophy Type 1 but Not from Myotonic Dystrophy Type 2

Cell Membrane Integrity in Myotonic Dystrophy Type 1: Implications for Therapy

Reconstructing the Rasch-Built Myotonic Dystrophy Type 1 Activity and Participation Scale

Deregulated MicroRNAs in Myotonic Dystrophy Type 2

Characteristic MRI Findings of upper Limb Muscle Involvement in Myotonic Dystrophy Type 1

RBFOX1 Cooperates with MBNL1 to Control Splicing in Muscle, Including Events Altered in Myotonic Dystrophy Type 1

Serum Cytokines as Biomarkers in Islet Cell Transplantation for Type 1 Diabetes

Overweight Is an Independent Risk Factor for Reduced Lung Volumes in Myotonic Dystrophy Type 1

Six Serum miRNAs Fail to Validate as Myotonic Dystrophy Type 1 Biomarkers