NDLI: Different Gene Expression Signatures in Children and Adults with Celiac Disease

Content Provider	PubMed Central
Author	Pascual, V. Medrano, L. M. López-palacios, N. Bodas, A. Dema, B. Fernández-arquero, M. González-pérez, B. Salazar, I. Núñez, C.
Editor	Pietropaolo, Massimo
Copyright Year	2016
Abstract	Celiac disease (CD) is developed after gluten ingestion in genetically susceptible individuals. It can appear at any time in life, but some differences are commonly observed between individuals with onset early in life or in adulthood. We aimed to investigate the molecular basis underlying those differences. We collected 19 duodenal biopsies of children and adults with CD and compared the expression of 38 selected genes between each other and with the observed in 13 non-CD controls matched by age. A Bayesian methodology was used to analyze the differences of gene expression between groups. We found seven genes with a similarly altered expression in children and adults with CD when compared to controls (C2orf74, CCR6, FASLG, JAK2, IL23A, TAGAP and UBE2L3). Differences were observed in 13 genes: six genes being altered only in adults (IL1RL1, CD28, STAT3, TMEM187, VAMP3 and ZFP36L1) and two only in children (TNFSF18 and ICOSLG); and four genes showing a significantly higher alteration in adults (CCR4, IL6, IL18RAP and PLEK) and one in children (C1orf106). This is the first extensive study comparing gene expression in children and adults with CD. Differences in the expression level of several genes were found between groups, being notorious the higher alteration observed in adults. Further research is needed to evaluate the possible genetic influence underlying these changes and the specific functional consequences of the reported differences.
Related Links	http://dx.doi.org/10.1371/journal.pone.0146276
Starting Page	146276
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	2
Volume Number	11
Language	English
Publisher	Public Library of Science
Publisher Date	2016-02-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Identification of Common Prognostic Gene Expression Signatures with Biological Meanings from Microarray Gene Expression Datasets

Markers of Celiac Disease and Gluten Sensitivity in Children with Autism

Serological Assessment for Celiac Disease in IgA Deficient Adults

Effect of a Gluten-Free Diet on Cortical Excitability in Adults with Celiac Disease

Gene Expression Profile of Peripheral Blood Monocytes: A Step towards the Molecular Diagnosis of Celiac Disease?

Dynamic Gene Expression in the Human Cerebral Cortex Distinguishes Children from Adults

Cross-Platform Prediction of Gene Expression Signatures

Correction: Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

Gene Expression Profiling Identifies IRF4-Associated Molecular Signatures in Hematological Malignancies

Different Gene Expression Signatures in Children and Adults with Celiac Disease

Similar Documents

Identification of Common Prognostic Gene Expression Signatures with Biological Meanings from Microarray Gene Expression Datasets

Markers of Celiac Disease and Gluten Sensitivity in Children with Autism

Serological Assessment for Celiac Disease in IgA Deficient Adults

Effect of a Gluten-Free Diet on Cortical Excitability in Adults with Celiac Disease

Gene Expression Profile of Peripheral Blood Monocytes: A Step towards the Molecular Diagnosis of Celiac Disease?

Dynamic Gene Expression in the Human Cerebral Cortex Distinguishes Children from Adults

Cross-Platform Prediction of Gene Expression Signatures

Correction: Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

Gene Expression Profiling Identifies IRF4-Associated Molecular Signatures in Hematological Malignancies

Different Gene Expression Signatures in Children and Adults with Celiac Disease