NDLI: The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling

Content Provider	PubMed Central
Author	Schaap, Pauline Barrantes, Israel Minx, Pat Sasaki, Narie Anderson, Roger W. Marianne, Bénard Biggar, Kyle K. Buchler, Nicolas E. Bundschuh, Ralf Chen, Xiao Fronick, Catrina Fulton, Lucinda Golderer, Georg Jahn, Niels Knoop, Volker Landweber, Laura F. Maric, Chrystelle Miller, Dennis Noegel, Angelika A. Peace, Rob Pierron, Gérard Sasaki, Taeko Schallenberg-rüdinger, Mareike Schleicher, Michael Singh, Reema Spaller, Thomas Storey, Kenneth B. Suzuki, Takamasa Tomlinson, Chad Tyson, John J. Warren, Wesley C. Werner, Ernst R. Gabriele, Werner-felmayer Wilson, Richard K. Winckler, Thomas Gott, Jonatha M. Glöckner, Gernot Marwan, Wolfgang
Copyright Year	2015
Abstract	Physarum polycephalum is a well-studied microbial eukaryote with unique experimental attributes relative to other experimental model organisms. It has a sophisticated life cycle with several distinct stages including amoebal, flagellated, and plasmodial cells. It is unusual in switching between open and closed mitosis according to specific life-cycle stages. Here we present the analysis of the genome of this enigmatic and important model organism and compare it with closely related species. The genome is littered with simple and complex repeats and the coding regions are frequently interrupted by introns with a mean size of 100 bases. Complemented with extensive transcriptome data, we define approximately 31,000 gene loci, providing unexpected insights into early eukaryote evolution. We describe extensive use of histidine kinase-based two-component systems and tyrosine kinase signaling, the presence of bacterial and plant type photoreceptors (phytochromes, cryptochrome, and phototropin) and of plant-type pentatricopeptide repeat proteins, as well as metabolic pathways, and a cell cycle control system typically found in more complex eukaryotes. Our analysis characterizes P. polycephalum as a prototypical eukaryote with features attributed to the last common ancestor of Amorphea, that is, the Amoebozoa and Opisthokonts. Specifically, the presence of tyrosine kinases in Acanthamoeba and Physarum as representatives of two distantly related subdivisions of Amoebozoa argues against the later emergence of tyrosine kinase signaling in the opisthokont lineage and also against the acquisition by horizontal gene transfer.
Related Links	http://dx.doi.org/10.1093/gbe/evv237
Ending Page	125
Page Count	17
Starting Page	109
File Format	PDF
ISSN	17596653
e-ISSN	17596653
Journal	Genome Biology and Evolution
Issue Number	1
Volume Number	8
Language	English
Publisher	Oxford University Press
Publisher Date	2016-01-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Genetics Ecology, Evolution, Behavior and Systematics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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