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  1. Autoimmunity
  2. Year: 2013, Volume: 46
  3. Year: 2013, Volume: 46, Issue: 2
  4. AID in aging and autoimmune diseases
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Year: 2015, Volume: 48
Year: 2014, Volume: 47
Year: 2013, Volume: 46
Year: 2013, Volume: 46, Issue: 8
Year: 2013, Volume: 46, Issue: 6
Year: 2013, Volume: 46, Issue: 3
Year: 2013, Volume: 46, Issue: 2
Regulation of Aicda expression and AID activity
Somatic Mutagenesis in Autoimmunity
Potential roles of Activation-Induced cytidine Deaminase in promotion or prevention of autoimmunity in humans
Critical role of activation induced cytidine deaminase in Experimental Autoimmune Encephalomyelitis
AID in aging and autoimmune diseases
Year: 2013, Volume: 46, Issue: 1
Year: 2012, Volume: 45
Year: 2011, Volume: 44
Year: 2010, Volume: 43
Year: 2009, Volume: 42
Year: 2008, Volume: 41
Year: 2007, Volume: 40
Year: 2004, Volume: 37
Year: 2002, Volume: 35
Year: 1994, Volume: 19
Year: 1992, Volume: 12

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AID in aging and autoimmune diseases

Content Provider PubMed Central
Author Frasca, Daniela Andrisani, Gianluca Diaz, Alain Felice, Carla Guidi, Luisa Blomberg, Bonnie B.
Abstract The aim of this study was to evaluate the quality of B cell responses in patients with Inflammatory Bowel Disease (IBD) and healthy individuals of different ages, vaccinated with the pandemic (p)2009 influenza vaccine. The in vivo response was measured by the hemagglutination inhibition (HAI) assay, which represents the most established correlate with vaccine protectiveness. The in vitro response was measured by activation-induced cytidine deaminase (AID) in cultures of vaccine-stimulated PBMC. Both responses are somewhat impaired in IBD patients undergoing anti-TNF-α treatment but these are much more decreased in IBD patients undergoing treatment with anti-TNF-α and immunosuppressive (IS) drugs. These latter patients had in vivo and in vitro B cell responses similar to those of elderly individuals. Moreover, as we have previously demonstrated in healthy subjects, the in vitro response to the polyclonal stimulus CpG may be used as a biomarker for subsequent vaccine response and AID activation is correlated with the serum response in IBD patients, as it is in healthy individuals. These results altogether indicate that IBD patients on anti-TNF-α and IS have significantly impaired in vivo and in vitro B cell responses, as compared to those on monotherapy. This is the first report to demonstrate that B cell defects, as measured by the autonomous AID reporter, in IBD patients contribute to reduced humoral responses to the influenza vaccine, as we have previously shown for elderly individuals.
Related Links http://dx.doi.org/10.3109/08916934.2012.750300
Ending Page 175
Page Count 8
Starting Page 168
File Format PDF
ISSN 08916934
e-ISSN 1607842X
Journal Autoimmunity
Issue Number 2
Volume Number 46
Language English
Publisher Date 2013-03-01
Access Restriction Open
Subject Keyword Immunology Immunology and Allergy Research in Higher Education
Content Type Text
Resource Type Article
Subject Immunology and Allergy Immunology
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