NDLI: Selective Loss of Early Differentiated, Highly FunctionalPD1high CD4 T Cells with HIV Progression

Content Provider	PubMed Central
Author	Paris, Robert M. Petrovas, Constantinos Sara, Ferrando-martinez Moysi, Eirini Boswell, Kristin L. Archer, Eva Yamamoto, Takuya David, Ambrozak Casazza, Joseph P. Haubrich, Richard Connors, Mark Ake, Julie Kim, Jerome H. Koup, Richard A.
Editor	Derya, Unutmaz
Abstract	The role of PD-1 expression on CD4 T cells during HIV infection is not wellunderstood. Here, we describe the differential expression of PD-1 inCD127high CD4 T cells within the early/intermediate differentiated (EI)(CD27highCD45RAlow) T cell population among uninfected andHIV-infected subjects, with higher expression associated with decreased viralreplication (HIV-1 viral load). A significant loss of circulatingPD-1highCTLA-4low CD4 T cells was found specifically in theCD127highCD27highCD45RAlow compartment, whileinitiation of antiretroviral treatment, particularly in subjects with advanceddisease, reversed these dynamics. Increased HIV-1 Gag DNA was also found inPD-1high compared to PD-1low ED CD4 T cells. In line with anincreased susceptibility to HIV infection, PD-1 expression in this CD4 T cell subsetwas associated with increased activation and expression of the HIV co-receptor, CCR5.Rather than exhaustion, this population produced more IFN-g, MIP1-a, IL-4, IL-10, andIL-17a compared to PD-1low EI CD4 T cells. In line with our previousfindings, PD-1high EI CD4 T cells were also characterized by a highexpression of CCR7, CXCR5 and CCR6, a phenotype associated with increased invitro B cell help. Our data show that expression of PD-1 onearly-differentiated CD4 T cells may represent a population that is highlyfunctional, more susceptible to HIV infection and selectively lost in chronic HIVinfection.
Related Links	http://dx.doi.org/10.1371/journal.pone.0144767
Starting Page	144767
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	12
Volume Number	10
Language	English
Publisher	Public Library of Science
Publisher Date	2015-12-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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