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| Content Provider | PubMed Central |
|---|---|
| Author | Dean, Franckaert Schlenner, Susan M. Heirman, Nathalie Gill, Jason Gabriel, Skogberg Ekwall, Olov Put, Karen Linterman, Michelle A. Dooley, James Liston, Adrian |
| Copyright Year | 2015 |
| Abstract | The thymus is the organ devoted to T-cell production. The thymus undergoes multiple rounds of atrophy and redevelopment before degenerating with age in a process known as involution. This process is poorly understood, despite the influence the phenomenon has on peripheral T-cell numbers. Here we have investigated the FVB/N mouse strain, which displays premature thymic involution. We find multiple architectural and cellular features that precede thymic involution, including disruption of the epithelial–endothelial relationship and a progressive loss of pro-T cells. The architectural features, reminiscent of the human thymus, are intrinsic to the nonhematopoietic compartment and are neither necessary nor sufficient for thymic involution. By contrast, the loss of pro-T cells is intrinsic to the hematopoietic compartment, and is sufficient to drive premature involution. These results identify pro-T-cell loss as the main driver of premature thymic involution, and highlight the plasticity of the thymic stroma, capable of maintaining function across diverse interstrain architectures. |
| Related Links | http://dx.doi.org/10.1002/eji.201445277 |
| Ending Page | 1547 |
| Page Count | 13 |
| Starting Page | 1535 |
| File Format | |
| ISSN | 00142980 |
| e-ISSN | 15214141 |
| Journal | European Journal of Immunology |
| Issue Number | 5 |
| Volume Number | 45 |
| Language | English |
| Publisher | John Wiley & Sons, Ltd |
| Publisher Date | 2015-05-01 |
| Access Restriction | Open |
| Rights Holder | John Wiley & Sons, Ltd |
| Subject Keyword | Immunology Immunology and Allergy Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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