NDLI: Premature thymic involution is independent of structural plasticity of the thymic stroma

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Premature thymic involution is independent of structural plasticity of the thymic stroma

Content Provider	Semantic Scholar
Author	Franckaert, Dean Schlenner, Susan M. Heirman, Nathalie Gill, Jason S. Skogberg, Gabriel Ekwall, Olov Put, Karen Linterman, Michelle A. Dooley, James Liston, Adrian
Copyright Year	2015
Abstract	The thymus is the organ devoted to T-cell production. The thymus undergoes multiple rounds of atrophy and redevelopment before degenerating with age in a process known as involution. This process is poorly understood, despite the influence the phenomenon has on peripheral T-cell numbers. Here we have investigated the FVB/N mouse strain, which displays premature thymic involution. We find multiple architectural and cellular features that precede thymic involution, including disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells. The architectural features, reminiscent of the human thymus, are intrinsic to the nonhematopoietic compartment and are neither necessary nor sufficient for thymic involution. By contrast, the loss of pro-T cells is intrinsic to the hematopoietic compartment, and is sufficient to drive premature involution. These results identify pro-T-cell loss as the main driver of premature thymic involution, and highlight the plasticity of the thymic stroma, capable of maintaining function across diverse interstrain architectures.
Starting Page	1535
Ending Page	1547
Page Count	13
File Format	PDF HTM / HTML
DOI	10.1002/eji.201445277
PubMed reference number	25627671
Journal	Medline
Volume Number	45
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/a2/eji0045-1535.PMC4670717.pdf
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/4e/a2/eji0045-1535.PMC4670717.pdf
Alternate Webpage(s)	https://doi.org/10.1002/eji.201445277
Journal	European journal of immunology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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