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| Content Provider | PubMed Central |
|---|---|
| Author | Kao, Ming-chang Chung, Chih-yang Chang, Ya-ying Lin, Chih-kung Sheu, Joen-rong Huang, Chun-jen |
| Copyright Year | 2015 |
| Abstract | Limb ischemia/reperfusion (I/R) causes oxidation and inflammation and subsequently induces muscle and kidney injuries. Cepharanthine, a natural plant alkaloid, possesses anti-inflammatory and antioxidative properties. We elucidated the salutary effects of cepharanthine against muscle and kidney injuries following limb I/R. Adult male rats were randomized to receive I/R or I/R plus cepharanthine. I/R was achieved by applying tourniquet high around each thigh for 3 hours followed by reperfusion for 24 hours. Cepharanthine (10 mg/kg, intraperitoneal) was injected immediately before reperfusion. After euthanization, degrees of tissue injury, inflammation, and oxidation were examined. Our data revealed that the I/R group had significant increases in injury biomarker concentrations of muscle (creatine kinase and lactate dehydrogenase) and kidney (creatinine, neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1). Histological assays revealed moderate muscle and kidney injury characteristics in the I/R group. The I/R group also had significant increases in concentrations of inflammatory molecules (interleukin-6, macrophage inflammatory protein-2, and prostaglandin E2) and reactive nitrogen species (nitric oxide) as well as lipid peroxidation (malondialdehyde). Of note, these effects of limb I/R could be mitigated by cepharanthine. These data confirmed that cepharanthine attenuated muscle and kidney injuries induced by limb I/R. The mechanisms may involve its anti-inflammatory and antioxidative capacities. |
| Related Links | http://dx.doi.org/10.1155/2015/504061 |
| Starting Page | 504061 |
| File Format | |
| ISSN | 1741427X |
| e-ISSN | 17414288 |
| Journal | Evidence-based Complementary and Alternative Medicine : eCAM |
| Volume Number | 2015 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2015-01-01 |
| Access Restriction | Open |
| Rights Holder | Hindawi Publishing Corporation |
| Subject Keyword | Complementary and alternative medicine Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Complementary and Alternative Medicine |
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