NDLI: Bai-Hu-Jia-Ren-Shen-Tang Decoction Reduces Fatty Liver by Activating AMP-Activated Protein Kinase In Vitro and In Vivo

Content Provider	PubMed Central
Author	Liu, Hui-kang Hung, Tzu-min Huang, Hsiu-chen Lee, I-jung Chang, Chia-chuan Cheng, Jing-jy Lin, Lie-chwen Huang, Cheng
Copyright Year	2015
Abstract	Obesity and associated conditions, such as type 2 diabetes mellitus (T2DM) andnonalcoholic fatty liver disease (NAFLD), are currently a worldwide health problem.In Asian traditional medicine, Bai-Hu-Jia-Ren-Shen-Tang (BHJRST) is widely used indiabetes patients to reduce thirst. However, whether it has a therapeutic effect onT2DM or NAFLD is not known. The aim of this study was to examine whether BHJRSThad a lipid-lowering effect using a HuS-E/2 cell model of fatty liver induced by palmitateand in a db/db mouse model of dyslipidemia. Incubation of HuS-E/2 cells with palmitatemarkedly increased lipid accumulation and expression of adipose triglyceride lipase (ATGL),which is involved in lipolysis. BHJRST significantly decreased lipid accumulation and increasedATGL levels and phosphorylation of AMP-activated protein kinase (AMPK)and its primary downstream target, acetyl-CoA carboxylase (ACC), which areinvolved in fatty acid oxidation. Furthermore, after twice daily oral administrationfor six weeks, BHJRST significantly reduced hepatic fat accumulation in db/db mice,as demonstrated by increased hepatic AMPK and ACC phosphorylation, reduced serumtriglyceride levels, and reduced hepatic total lipid content. The results show that BHJRSThas a lipid-lowering effect in the liver that is mediated by activation of the AMPK signaling pathway.
Related Links	http://dx.doi.org/10.1155/2015/651734
Starting Page	651734
File Format	PDF
ISSN	17414288
e-ISSN	17414288
Journal	Evidence-based Complementary and Alternative Medicine : eCAM
Volume Number	2015
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2015-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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