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| Content Provider | PubMed Central |
|---|---|
| Author | Davide, Michieletto Davide, Marenduzzo Orlandini, Enzo |
| Abstract | Gel electrophoresis is a ubiquitous biophysical technique. It consists of dragging charged biopolymers through a porous gel, by applying an electric field. Because the migration speed depends on topology, this method can be used to classify DNA knots. Currently, electrophoresis relies on empirical observations, and its theoretical understanding is limited. No theory can explain why knot mobility under strong fields depends nonmonotonically on complexity. Our study reveals a possible reason: Although complex knots have a smaller size, and hence move faster through the gel, they can become severely entangled with the gel, causing longer pauses. Our results can improve the design of future electrophoresis experiments. |
| Related Links | http://dx.doi.org/10.1073/pnas.1506907112 |
| Starting Page | 5471 |
| File Format | |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 40 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-10-06 |
| Access Restriction | Open |
| Rights Holder | National Academy of Sciences |
| Subject Keyword | General Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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