NDLI: Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of marine bacteria

Content Provider	PubMed Central
Author	Ishii, Eiji Chiba, Shinobu Hashimoto, Narimasa Kojima, Seiji Homma, Michio Ito, Koreaki Akiyama, Yoshinori Mori, Hiroyuki
Abstract	Bacteria living in seawater must cope with low-sodium environments that they may encounter. Here we show an unexpected finding that remodeling of the Sec protein export machinery plays a pivotal role in this adaptation. Vibrio alginolyticus possesses alternative SecDF1 and SecDF2 homologs that use the transmembrane gradient of Na+ and that of H+, respectively, to enhance protein export by cooperating with the SecYEG translocon. The synthesis of SecDF2 is induced in low-Na+ environments, and this induction is essential for the bacterium to survive low salinity. Remarkably, the Vibrio species use a nascent polypeptide, VemP, to monitor the functional state of the Sec pathway and to up-regulate translation of SecDF2 when activity of the SecDF1-containing Sec machinery declines.
Related Links	http://dx.doi.org/10.1073/pnas.1513001112
Starting Page	5513
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	40
Volume Number	112
Language	English
Publisher	National Academy of Sciences
Publisher Date	2015-10-06
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of marine bacteria