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| Content Provider | PubMed Central |
|---|---|
| Author | Song, Yu-feng Luo, Zhi Huang, Chao Chen, Qi-liang Pan, Yaâ xiong Xu, Yi-huan |
| Copyright Year | 2015 |
| Abstract | Two endoplasmic reticulum (ER) molecular chaperones [glucose-regulated protein 78 (grp78) and calreticulin (crt)] and three ER stress sensors [PKR-like ER kinase (perk), inositol requiring enzyme (ire)-1α, and activating transcription factor (atf)-6α] cDNAs were first characterized from yellow catfish, Pelteobagrus fulvidraco. The predicted amino acid sequences for the yellow catfish grp78, crt, perk, ire-1α, and atf-6α revealed that the proteins contained all of the structural features that were characteristic of the five genes in other species, including the KDEL motif, signal peptide, sensor domain, and effector domain. mRNAs of the five genes mentioned above were expressed in various tissues, but their mRNA levels varied among tissues. Dietary Cu excess, but not Cu deficiency, activated the chaperones (grp78 and crt) and folding sensors in ER, and the UPR signaling pathways (i.e., perk–eif2α and the ire1–xbp1) in a tissue-specific manner. For the first time, our study cloned grp78, crt, perk, ire-1α, and atf-6α genes in yellow catfish and demonstrated their differential expression among tissues. Moreover, the present study also indicated differential regulation of these ER stress–related genes by dietary Cu deficiency and excess, which will be beneficial for us to evaluate effects of dietary Cu levels in fish at the molecular level, based on the upstream pathway of lipid metabolism (the ER) and thus provide novel insights regarding the nutrition of Cu in fish. |
| Related Links | http://dx.doi.org/10.1534/g3.115.019950 |
| Ending Page | 2104 |
| Page Count | 14 |
| Starting Page | 2091 |
| File Format | |
| ISSN | 21601836 |
| e-ISSN | 21601836 |
| Journal | G3: Genes|Genomes|Genetics |
| Issue Number | 10 |
| Volume Number | 5 |
| Language | English |
| Publisher | Genetics Society of America |
| Publisher Date | 2015-10-02 |
| Access Restriction | Open |
| Rights Holder | Genetics Society of America |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Molecular Biology Genetics (clinical) |
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