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| Content Provider | PubMed Central |
|---|---|
| Author | Wang, Yizhou Smith, Kristina M. Taylor, John W. Freitag, Michael Stajich, Jason E. |
| Copyright Year | 2015 |
| Abstract | Genome defense likely evolved to curtail the spread of transposable elements and invading viruses. A combination of effective defense mechanisms has been shown to limit colonization of the Neurospora crassa genome by transposable elements. A novel DNA transposon named Sly1-1 was discovered in the genome of the most widely used laboratory “wild-type” strain FGSC 2489 (OR74A). Meiotic silencing by unpaired DNA, also simply called meiotic silencing, prevents the expression of regions of the genome that are unpaired during karyogamy. This mechanism is posttranscriptional and is proposed to involve the production of small RNA, so-called masiRNAs, by proteins homologous to those involved in RNA interference−silencing pathways in animals, fungi, and plants. Here, we demonstrate production of small RNAs when Sly1-1 was unpaired in a cross between two wild-type strains. These small RNAs are dependent on SAD-1, an RNA-dependent RNA polymerase necessary for meiotic silencing. We present the first case of endogenously produced masiRNA from a novel N. crassa DNA transposable element. |
| Related Links | http://dx.doi.org/10.1534/g3.115.017921 |
| Ending Page | 1960 |
| Page Count | 12 |
| Starting Page | 1949 |
| File Format | |
| ISSN | 21601836 |
| e-ISSN | 21601836 |
| Journal | G3: Genes|Genomes|Genetics |
| Issue Number | 10 |
| Volume Number | 5 |
| Language | English |
| Publisher | Genetics Society of America |
| Publisher Date | 2015-06-23 |
| Access Restriction | Open |
| Rights Holder | Genetics Society of America |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Molecular Biology Genetics (clinical) |
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