NDLI: Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma

Content Provider	PubMed Central
Author	Besse, Lenka Lenka, Sedlarikova Kryukov, Fedor Jana, Nekvindova Radova, Lenka Slaby, Ondrej Petr, Kuglik Almasi, Martina Penka, Miroslav Krejci, Marta Adam, Zdenek Pour, Ludek Sabina, Sevcikova Hajek, Roman
Editor	Li, Zheng
Copyright Year	2015
Abstract	Poor outcome of extramedullary disease in multiple myeloma patients and lack of outcome predictors prompt continued search for new markers of the disease. In this report, we show circulating microRNA distinguishing multiple myeloma patients with extramedullary disease from myeloma patients without such manifestation and from healthy donors. MicroRNA-130a was identified by TaqMan Low Density Arrays and verified by quantitative PCR on 144 serum samples (59 multiple myeloma, 55 myeloma with extramedullary disease, 30 healthy donors) in test and validation cohorts as being down-regulated in myeloma patients with extramedullary disease. Circulating microRNA-130a distinguished myeloma patients with extramedullary disease from healthy donors with specificity of 90.0% and sensitivity of 77.1%, patients with extramedullary disease from newly diagnosed multiple myeloma patients with specificity of 77.1% and sensitivity of 34.3% in the test cohort and with specificity of 91.7% and sensitivity of 30.0% in the validation cohort of patients. Circulating microRNA-130a in patients with extramedullary myeloma was associated with bone marrow plasma cells infiltration. Further, microRNA-130a was decreased in bone marrow plasma cells obtained from patients with extramedullary myeloma in comparison to bone marrow plasma cells of myeloma patients without such manifestation, but it was increased in tumor site plasma cells of patients with extramedullary disease compared to bone marrow plasma cells of such patients (p<0.0001). Together, our data suggest connection between lower level of microRNA-130a and extramedullary disease and prompt further work to evaluate this miRNA as a marker of extramedullary disease in multiple myeloma.
Related Links	http://dx.doi.org/10.1371/journal.pone.0137294
Starting Page	137294
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	9
Volume Number	10
Language	English
Publisher	Public Library of Science
Publisher Date	2015-09-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Serum MicroRNA-21 as a Diagnostic Marker for Lung Carcinoma: A Systematic Review and Meta-Analysis

Secretome-Based Identification of ULBP2 as a Novel Serum Marker for Pancreatic Cancer Detection

Serum CXCL16 as a Novel Marker of Renal Injury in Type 2 Diabetes Mellitus

Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma

Circulating miRNAs as Potential Marker for Pulmonary Hypertension

Translational Control of FOG-2 Expression in Cardiomyocytes by MicroRNA-130a

Circulating MiR-125b as a Marker Predicting Chemoresistance in Breast Cancer

MicroRNA-302a Functions as a Putative Tumor Suppressor in Colon Cancer by Targeting Akt

MicroRNA-330-5p as a Putative Modulator of Neoadjuvant Chemoradiotherapy Sensitivity in Oesophageal Adenocarcinoma

Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma

Similar Documents

Serum MicroRNA-21 as a Diagnostic Marker for Lung Carcinoma: A Systematic Review and Meta-Analysis

Secretome-Based Identification of ULBP2 as a Novel Serum Marker for Pancreatic Cancer Detection

Serum CXCL16 as a Novel Marker of Renal Injury in Type 2 Diabetes Mellitus

Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma

Circulating miRNAs as Potential Marker for Pulmonary Hypertension

Translational Control of FOG-2 Expression in Cardiomyocytes by MicroRNA-130a

Circulating MiR-125b as a Marker Predicting Chemoresistance in Breast Cancer

MicroRNA-302a Functions as a Putative Tumor Suppressor in Colon Cancer by Targeting Akt

MicroRNA-330-5p as a Putative Modulator of Neoadjuvant Chemoradiotherapy Sensitivity in Oesophageal Adenocarcinoma

Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma