NDLI: Promoter-Dependent Translation Controlled by p54nrb and hnRNPM during Myoblast Differentiation

Content Provider	PubMed Central
Author	Ainaoui, Nadera Hantelys, Fransky Edith, Renaud-gabardos Bunel, Morgane Lopez, Frédéric Pujol, Françoise Planes, Remi Bahraoui, Elmostafa Carole, Pichereaux Odile, Burlet-schiltz Parini, Angelo Barbara, Garmy-susini Prats, Anne-catherine
Editor	Kim, Yoon Ki
Copyright Year	2015
Abstract	Fibroblast growth factor 1 (FGF1) is induced during myoblast differentiation at both transcriptional and translational levels. Here, we identify hnRNPM and p54nrb/NONO present in protein complexes bound to the FGF1 promoter and to the mRNA internal ribosome entry site (IRES). Knockdown or overexpression of these proteins indicate that they cooperate in activating IRES-dependent translation during myoblast differentiation, in a promoter-dependent manner. Importantly, mRNA transfection and promoter deletion experiments clearly demonstrate the impact of the FGF1 promoter on the activation of IRES-dependent translation via p54nrb and hnRNPM. Accordingly, knockdown of either p54 or hnRNPM also blocks endogenous FGF1 induction and myotube formation, demonstrating the physiological relevance of this mechanism and the role of these two proteins in myogenesis. Our study demonstrates the cooperative function of hnRNPM and p54nrb as regulators of IRES-dependent translation and indicates the involvement of a promoter-dependent mechanism.
Related Links	http://dx.doi.org/10.1371/journal.pone.0136466
Starting Page	136466
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	9
Volume Number	10
Language	English
Publisher	Public Library of Science
Publisher Date	2015-09-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Stac3 Inhibits Myoblast Differentiation into Myotubes

Correction: Stac3 Inhibits Myoblast Differentiation into Myotubes

Notch Pathway Activation Contributes to Inhibition of C2C12 Myoblast Differentiation by Ethanol

Adhesion Proteins - An Impact on Skeletal Myoblast Differentiation

Transthyretin Is a Key Regulator of Myoblast Differentiation

LKB1 Destabilizes Microtubules in Myoblasts and Contributes to Myoblast Differentiation

RNAi Screen Reveals Potentially Novel Roles of Cytokines in Myoblast Differentiation

Krüppel Like Factor 4 Promoter Undergoes Active Demethylation during Monocyte/Macrophage Differentiation

Protein Kinase D2 Is an Essential Regulator of Murine Myoblast Differentiation

Promoter-Dependent Translation Controlled by p54nrb and hnRNPM during Myoblast Differentiation

Similar Documents

Stac3 Inhibits Myoblast Differentiation into Myotubes

Correction: Stac3 Inhibits Myoblast Differentiation into Myotubes

Notch Pathway Activation Contributes to Inhibition of C2C12 Myoblast Differentiation by Ethanol

Adhesion Proteins - An Impact on Skeletal Myoblast Differentiation

Transthyretin Is a Key Regulator of Myoblast Differentiation

LKB1 Destabilizes Microtubules in Myoblasts and Contributes to Myoblast Differentiation

RNAi Screen Reveals Potentially Novel Roles of Cytokines in Myoblast Differentiation

Krüppel Like Factor 4 Promoter Undergoes Active Demethylation during Monocyte/Macrophage Differentiation

Protein Kinase D2 Is an Essential Regulator of Murine Myoblast Differentiation

Promoter-Dependent Translation Controlled by p54nrb and hnRNPM during Myoblast Differentiation