NDLI: Aquaporins Mediate Silicon Transport in Humans

Content Provider	PubMed Central
Author	Garneau, Alexandre P. Carpentier, Gabriel A. Marcoux, Andrée-anne Frenette-cotton, Rachelle Simard, Charles F. Wilfried, Rémus-borel Caron, Luc Jacob-wagner, Mariève Noël, Micheline Powell, Jonathan J. Bélanger, Richard Côté, François Isenring, Paul
Editor	Gerós, Hernâni
Copyright Year	2015
Abstract	In animals, silicon is an abundant and differentially distributed trace element that is believed to play important biological functions. One would thus expect silicon concentrations in body fluids to be regulated by silicon transporters at the surface of many cell types. Curiously, however, and even though they exist in plants and algae, no such transporters have been identified to date in vertebrates. Here, we show for the first time that the human aquaglyceroporins, i.e., AQP3, AQP7, AQP9 and AQP10 can act as silicon transporters in both Xenopus laevis oocytes and HEK-293 cells. In particular, heterologously expressed AQP7, AQP9 and AQP10 are all able to induce robust, saturable, phloretin-sensitive silicon transport activity in the range that was observed for low silicon rice 1 (lsi1), a silicon transporter in plant. Furthermore, we show that the aquaglyceroporins appear as relevant silicon permeation pathways in both mice and humans based on 1) the kinetics of substrate transport, 2) their presence in tissues where silicon is presumed to play key roles and 3) their transcriptional responses to changes in dietary silicon. Taken together, our data provide new evidence that silicon is a potentially important biological element in animals and that its body distribution is regulated. They should open up original areas of investigations aimed at deciphering the true physiological role of silicon in vertebrates.
Related Links	http://dx.doi.org/10.1371/journal.pone.0136149
Starting Page	136149
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	8
Volume Number	10
Language	English
Publisher	Public Library of Science
Publisher Date	2015-08-27
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Optimizing water permeability through the hourglass shape of aquaporins.

Mechanism of selectivity in aquaporins and aquaglyceroporins

Osmotic water transport in aquaporins: evidence for a stochastic mechanism

Transport spectroscopy of coupled donors in silicon nano-transistors

Water Transport in Aquaporins: Osmotic Permeability Matrix Analysis of Molecular Dynamics Simulations

Selective transport systems mediate sequestration of plant glucosides in leaf beetles: A molecular basis for adaptation and evolution

Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans

Heteromerization of PIP aquaporins affects their intrinsic permeability

Optimizing water permeability through the hourglass shape of aquaporins

Aquaporins Mediate Silicon Transport in Humans

Similar Documents

Optimizing water permeability through the hourglass shape of aquaporins.

Mechanism of selectivity in aquaporins and aquaglyceroporins

Osmotic water transport in aquaporins: evidence for a stochastic mechanism

Transport spectroscopy of coupled donors in silicon nano-transistors

Water Transport in Aquaporins: Osmotic Permeability Matrix Analysis of Molecular Dynamics Simulations

Selective transport systems mediate sequestration of plant glucosides in leaf beetles: A molecular basis for adaptation and evolution

Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans

Heteromerization of PIP aquaporins affects their intrinsic permeability

Optimizing water permeability through the hourglass shape of aquaporins

Aquaporins Mediate Silicon Transport in Humans