NDLI: Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke

Content Provider	PubMed Central
Author	Christine, Weinl Vega, Salvador Castaneda Riehle, Heidemarie Christine, Stritt Carsten, Calaminus Hartwig, Wolburg Mauel, Susanne Breithaupt, Angele Gruber, Achim D. Wasylyk, Bohdan Olson, Eric N. Adams, Ralf H. Pichler, Bernd J. Nordheim, Alfred
Abstract	Human cerebral small vessel disease (SVD) comprises age-associated intracerebral hemorrhages and global cognitive impairment, including vascular dementia. Human SVD presents in either familial or sporadic manifestation, involving either monogenic Mendelian defects or multitrait genetic variants. To better characterize the genetic and molecular mechanisms underlying SVD, appropriate animal models are needed. The Srf iECKO mouse model presented here resembles human SVD pathology with regard to intracerebral hemorrhage formation and vascular dementia, including variability in onset and progression of cerebral symptoms. The Serum Response Factor (SRF)/Myocardin Related Transcription Factor (MRTF) are shown to regulate the expression of genes, which are essential for the maintenance of blood–brain barrier function and cerebral microvessel integrity. These findings suggest impairment of SRF/MRTF-mediated gene control as a molecular mechanism contributing to human SVD.
Related Links	http://dx.doi.org/10.1073/pnas.1509047112
Ending Page	9919
Page Count	6
Starting Page	9914
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	32
Volume Number	112
Language	English
Publisher	National Academy of Sciences
Publisher Date	2015-08-11
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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