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| Content Provider | PubMed Central |
|---|---|
| Author | Pak, On Shun Young, Y. N. Marple, Gary R. Veerapaneni, Shravan Stone, Howard A. |
| Abstract | Mechanosensitive (MS) channels are membrane proteins that can be gated by membrane tension, and they play major roles in mechanosensation and mechanotransduction in cells. As a step in understanding the dynamics of a MS channel in membranes exposed to fluid flows, a multiscale continuum model is constructed to address how a MS channel in a vesicle membrane can be gated by flow-generated stresses in two physiological flows: planar shear flow and pressure-driven flow across a constriction channel. We demonstrate the opening/closing of a MS channel as a function of the flow strength and physical parameters. Our numerical results also suggest the possibility of utilizing fluid flows to deliver macromolecules (e.g., drugs) by gating MS channels reconstituted in liposomes in microfluidic platforms. |
| Related Links | http://dx.doi.org/10.1073/pnas.1512152112 |
| Ending Page | 9827 |
| Page Count | 6 |
| Starting Page | 9822 |
| File Format | |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 32 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-08-11 |
| Access Restriction | Open |
| Rights Holder | National Academy of Sciences |
| Subject Keyword | General Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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