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| Content Provider | PubMed Central |
|---|---|
| Author | Xiao, Juan Yang, Rongbing Biswas, Sangita Qin, Xin Zhang, Min Deng, Wenbin |
| Editor | Christoph, Kleinschnitz |
| Copyright Year | 2015 |
| Abstract | Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits. Current MS treatment regimens are insufficient to treat the irreversible neurological disabilities. Tremendous progress in the experimental and clinical applications of cell-based therapies has recognized stem cells as potential candidates for regenerative therapy for many neurodegenerative disorders including MS. Mesenchymal stem cells (MSC) and induced pluripotent stem cell (iPSCs) derived precursor cells can modulate the autoimmune response in the central nervous system (CNS) and promote endogenous remyelination and repair process in animal models. This review highlights studies involving the immunomodulatory and regenerative effects of mesenchymal stem cells and iPSCs derived cells in animal models, and their translation into immunomodulatory and neuroregenerative treatment strategies for MS. |
| Related Links | http://dx.doi.org/10.3390/ijms16059283 |
| Ending Page | 9302 |
| Page Count | 20 |
| Starting Page | 9283 |
| File Format | |
| ISSN | 14220067 |
| e-ISSN | 14220067 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 5 |
| Volume Number | 16 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2015-04-01 |
| Access Restriction | Open |
| Rights Holder | MDPI |
| Subject Keyword | Physical and Theoretical Chemistry Inorganic Chemistry Organic Chemistry Spectroscopy Molecular Biology Catalysis Computer Science Applications Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Organic Chemistry Medicine Molecular Biology Physical and Theoretical Chemistry Catalysis Inorganic Chemistry Computer Science Applications |
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