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| Content Provider | PubMed Central |
|---|---|
| Author | Vashisth, Priya Sharma, Mohit Nikhil, Kumar Singh, Harmeet Panwar, Richa Pruthi, Parul A. Pruthi, Vikas |
| Abstract | Ferulic acid (FA) is a polyphenolic phytonutrient which possesses strong antiproliferative effect; however, it has limited therapeutic applications due to its physiochemical instability and low bioavailability at the tumor site. In present study, these shortcomings associated with FA were overcome by fabricating FA-encapsulated poly(d,l-lactide-co-glycolide)/polyethylene oxide (PLGA/PEO) blend nanofibers using electrospinning technique. FESEM and fluorescence microscopic analysis imitates the smooth morphology and even distribution of FA within the polymeric nanofibers at optimum 2 wt% concentration of FA. The average diameters were recorded to be 150 ± 47.4 and 200 ± 79 nm for PLGA/PEO and FA-encapsulated PLGA/PEO nanofibers, respectively. The encapsulation, compatibility, and physical state of FA within the nanofibers were further confirmed by FTIR, TGA and XRD analysis. In vitro drug delivery studies demonstrated initial burst liberation of FA within 24 h followed by a sustained release for the subsequent time. MTT assay revealed the effectiveness of FA-encapsulated nanofibers against human breast carcinoma cells (MCF-7) cells as compared to control. FESEM and fluorescence microscopic analysis further confirmed the apoptotic effect of FA-encapsulated PLGA/PEO nanofibers against MCF-7. These fabricated nanofibers hold enormous potential to be used as a therapeutic agent for various biomedical applications. |
| Related Links | http://dx.doi.org/10.1007/s13205-014-0229-6 |
| Ending Page | 315 |
| Page Count | 13 |
| Starting Page | 303 |
| File Format | |
| ISSN | 21905738 |
| e-ISSN | 21905738 |
| Journal | 3 Biotech |
| Issue Number | 3 |
| Volume Number | 5 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2015-06-01 |
| Access Restriction | Open |
| Rights Holder | Springer Berlin Heidelberg |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Environmental Science Agricultural and Biological Sciences Biotechnology |
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