Antiproliferative activity of primates-consumed plants against MCF-7 human breast cancer cell lines

Content Provider	Semantic Scholar
Author	Subarnas, Anas Diantini, Ajeng Abdulah, Rizky Zuhrotun, Ade Yamazaki, Chiho Nakazawa, Mintao Koyama, Hiroshi
Copyright Year	2012
Abstract	Primate-consumed plants are assumed to be a promising source of therapeutic agents since primates can survive and be cured from any disease by their daily consumed food. In the course of our study to search for anticancer agents, we evaluated 42 species of plants usually consumed by primates for their antiproliferative activity against cell lines of human breast adenocarcinoma (MCF-7). In this study, crude ethanol extracts of the plants were tested using MTT (3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) assay. The results showed that four extracts of Dysoxylum caulostachyum, Eugenia aquea, Garcinia celebica, and Psychotria valentonic leaves strongly inhibited the MCF-7 cell proliferation with IC 50 values of 12, 58, 87, and 87 µg/ml, respectively. Further examination on the fractions of the four extracts indicated that the ethyl acetate fraction of D. caulostachyum , the n-hexane fractions of E. aquea and G. celebica, and the water fraction of P. valentonic were the most active fractions with the IC 50 of 78 , 24, 60, and 23 µg/ml, respectively. These results suggest that primate-consumed plants might have potential as a source of anticancer agents.
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Alternate Webpage(s)	http://www.e3journals.org/cms/articles/1336597606_EJMR-12-021_Galley%20Proof1.pdf
Language	English
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Resource Type	Article