NDLI: Local Definition of Ty1 Target Preference by Long Terminal Repeats and Clustered tRNA Genes

Content Provider	PubMed Central
Author	Bachman, Nurjana Eby, Yolanda Boeke, Jef D.
Copyright Year	2004
Abstract	LTR-containing retrotransposons reverse transcribe their RNA genomes, and the resulting cDNAs are integrated into the genome by the element-encoded integrase protein. The yeast LTR retrotransposon Ty1 preferentially integrates into a target window upstream of tDNAs (tRNA genes) in the yeast genome. We investigated the nature of these insertions and the target window on a genomic scale by analyzing several hundred de novo insertions upstream of tDNAs in two different multicopy gene families. The pattern of insertion upstream of tDNAs was nonrandom and periodic, with peaks separated by ∼80 bp. Insertions were not distributed equally throughout the genome, as certain tDNAs within a given family received higher frequencies of upstream Ty1 insertions than others. We showed that the presence and relative position of additional tDNAs and LTRs surrounding the target tDNA dramatically influenced the frequency of insertion events upstream of that target.
Related Links	http://dx.doi.org/10.1101/gr.2052904
Ending Page	1247
Page Count	16
Starting Page	1232
File Format	PDF
ISSN	10889051
Journal	Genome Research
Issue Number	7
Volume Number	14
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2004-06-01
Access Restriction	Open
Rights Holder	Cold Spring Harbor Laboratory Press
Subject Keyword	Genetics(clinical) Genetics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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Local definition of Ty1 target preference by long terminal repeats and clustered tRNA genes.

Increased Length of Long Terminal Repeats Inhibits Ty1 Transposition and Leads to the Formation of Tandem Multimers

Clustered tRNA genes in Schizosaccharomyces pombe centromeric DNA sequence repeats.

Localization of sequences required in cis for yeast Ty1 element transposition near the long terminal repeats: analysis of mini-Ty1 elements.

Hos2 and Set3 Promote Integration of Ty1 Retrotransposons at tRNA Genes in Saccharomyces cerevisiae

Influences of Histone Stoichiometry on the Target Site Preference of Retrotransposons Ty1 and Ty2 in Saccharomyces Cerevisiae

Trinucleotide repeats are clustered in regulatory genes in Saccharomyces cerevisiae.

Retrotransposon Ty1 integration targets specifically positioned asymmetric nucleosomal DNA segments in tRNA hotspots

Host genes that affect the target-site distribution of the yeast retrotransposon Ty1.

Local Definition of Ty1 Target Preference by Long Terminal Repeats and Clustered tRNA Genes

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Local definition of Ty1 target preference by long terminal repeats and clustered tRNA genes.

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Clustered tRNA genes in Schizosaccharomyces pombe centromeric DNA sequence repeats.

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