NDLI: The Insertional History of an Active Family of L1 Retrotransposons in Humans

Content Provider	PubMed Central
Author	Stéphane, Boissinot Entezam, Ali Young, Lynn Munson, Peter J. Furano, Anthony V.
Copyright Year	2004
Abstract	As humans contain a currently active L1 (LINE-1) non-LTR retrotransposon family (Ta-1), the human genome database likely provides only a partial picture of Ta-1-generated diversity. We used a non-biased method to clone Ta-1 retrotransposon-containing loci from representatives of four ethnic populations. We obtained 277 distinct Ta-1 loci and identified an additional 67 loci in the human genome database. This collection represents ∼90% of the Ta-1 population in the individuals examined and is thus more representative of the insertional history of Ta-1 than the human genome database, which lacked ∼40% of our cloned Ta-1 elements. As both polymorphic and fixed Ta-1 elements are as abundant in the GC-poor genomic regions as in ancestral L1 elements, the enrichment of L1 elements in GC-poor areas is likely due to insertional bias rather than selection. Although the chromosomal distribution of Ta-1 inserts is generally a function of chromosomal length and gene density, chromosome 4 significantly deviates from this pattern and has been much more hospitable to Ta-1 insertions than any other chromosome. Also, the intra-chromosomal distribution of Ta-1 elements is not uniform. Ta-1 elements tend to cluster, and the maximal gaps between Ta-1 inserts are larger than would be expected from a model of uniform random insertion.
Related Links	http://dx.doi.org/10.1101/gr.2326704
Ending Page	1231
Page Count	11
Starting Page	1221
File Format	PDF
ISSN	10889051
Journal	Genome Research
Issue Number	7
Volume Number	14
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2004-06-01
Access Restriction	Open
Rights Holder	Cold Spring Harbor Laboratory Press
Subject Keyword	Genetics(clinical) Genetics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The insertional history of an active family of L1 retrotransposons in humans.

More active human L1 retrotransposons produce longer insertions

Transduction-Specific ATLAS (TS-ATLAS) reveals a cohort of highly active L1 retrotransposons in human populations

The L1 family (KpnI family) sequence near the 3' end of human beta-globin gene may have been derived from an active L1 sequence.

Active Alu retrotransposons in the human genome

Two additional potential retrotransposons isolated from a human L1 subfamily that contains an active retrotransposable element.

More active human L1 retrotransposons produce longer insertions

A Novel Active L1 Retrotransposon Subfamily in the Mouse

The L1 family (Kpnl family) sequence near the 3' end of human β-globin gene may have been derived from an active L1 sequence

The Insertional History of an Active Family of L1 Retrotransposons in Humans

Similar Documents

The insertional history of an active family of L1 retrotransposons in humans.

More active human L1 retrotransposons produce longer insertions

Transduction-Specific ATLAS (TS-ATLAS) reveals a cohort of highly active L1 retrotransposons in human populations

The L1 family (KpnI family) sequence near the 3' end of human beta-globin gene may have been derived from an active L1 sequence.

Active Alu retrotransposons in the human genome

Two additional potential retrotransposons isolated from a human L1 subfamily that contains an active retrotransposable element.

More active human L1 retrotransposons produce longer insertions

A Novel Active L1 Retrotransposon Subfamily in the Mouse

The L1 family (Kpnl family) sequence near the 3' end of human β-globin gene may have been derived from an active L1 sequence

The Insertional History of an Active Family of L1 Retrotransposons in Humans