NDLI: Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide

Content Provider	PubMed Central
Author	Scuderi, Caterina Esposito, Giuseppe Blasio, Angelo Valenza, Marta Arietti, Pierluca Steardo Jr., Luca Rosa, Carnuccio Filippis, Daniele De Petrosino, Stefania Teresa, Iuvone Marzo, Vincenzo Di Luca, Steardo
Copyright Year	2011
Abstract	Emerging evidence indicates that astrogliosis is involved in the pathogenesis of neurodegenerative disorders. Our previous findings suggested cannabinoids and Autacoid Local Injury Antagonism Amides (ALIAmides) attenuate glial response in models of neurodegeneration. The present study was aimed at exploring palmitoylethanolamide (PEA) ability to mitigate β-amyloid (Aβ)-induced astrogliosis. Experiments were carried out to investigate PEA’s (10−7M) effects upon the expression and release of pro-inflammatory molecules in rat primary astrocytes activated by soluble Aβ1–42 (1 μg/ml) as well as to identify mechanisms responsible for such actions. The effects of Aβ and exogenous PEA on the astrocyte levels of the endocannabinoidsand of endogenous ALIAmides were also studied. The peroxisome proliferator-activated receptor (PPAR)-α (MK886, 3 μM) or PPAR-γ (GW9662, 9 nM) antagonists were co-administered with PEA. Aβ elevated endogenous PEA and d5–2-arachidonoylglycerol (2-AG) levels. Exogenous PEA blunted the Aβ-induced expression of pro-inflammatory molecules. This effect was reduced by PPAR-α antagonist. Moreover, this ALIAmide, like Aβ, increased 2-AG levels. These results indicate that PEA exhibits anti-inflammatory properties able to counteract Aβ-induced astrogliosis, and suggest novel treatment for neuroinflammatory/ neurodegenerative processes.
Related Links	http://dx.doi.org/10.1111/j.1582-4934.2011.01267.x
Ending Page	2674
Page Count	11
Starting Page	2664
File Format	PDF
ISSN	15821838
e-ISSN	15824934
Journal	Journal of Cellular and Molecular Medicine
Issue Number	12
Volume Number	15
Language	English
Publisher	Blackwell Publishing Ltd
Publisher Date	2011-12-01
Access Restriction	Open
Rights Holder	Blackwell Publishing Ltd
Subject Keyword	Molecular Medicine Cell Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Medicine

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