NDLI: Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes.

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Scientific conduct.

Cyclic nucleotide-gated channels: an expanding new family of ion channels.

Evolutionary origins of ion channels.

T-cell antigens in cancer.

Inactivation of gene expression in plants as a consequence of specific sequence duplication.

Cell biological mechanisms of multidrug resistance in tumors.

Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart.

An Escherichia coli homologue of eukaryotic potassium channel proteins.

Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.

Interaction between the N-terminal domain of the 230-kDa subunit and the TATA box-binding subunit of TFIID negatively regulates TATA-box binding.

Binding of histones H1 and H5 and their globular domains to four-way junction DNA.

Magnetic resonance microscopy of mouse embryos.

Bromophenacyl bromide binding to the actin-bundling protein l-plastin inhibits inositol trisphosphate-independent increase in Ca2+ in human neutrophils.

Insertional mutagenesis of Drosophila heterochromatin with single P elements.

Cation-promoted association of a regulatory and target protein is controlled by protein phosphorylation.

Dominant dystrophic epidermolysis bullosa: identification of a Gly-->Ser substitution in the triple-helical domain of type VII collagen.

Fine structure analysis of the WT1 gene in sporadic Wilms tumors.

Inhibition of cytochromes P4501A by nitric oxide.

Triterpene derivatives that block entry of human immunodeficiency virus type 1 into cells.

Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthase.

First epidermal growth factor-like domain of human blood coagulation factor IX is required for its activation by factor VIIa/tissue factor but not by factor XIa.

"...the tyranny of the lattice...".

Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappa B and induces nuclear translocation of transcription factor NF-kappa B proteins for transcriptional activation.

Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein.

A recombinant bisphosphoglycerate mutase variant with acid phosphatase homology degrades 2,3-diphosphoglycerate.

Compartmentalization of two forms of acetyl-CoA carboxylase in plants and the origin of their tolerance toward herbicides.

p53 and E2F-1 cooperate to mediate apoptosis.

Rodent BC1 RNA gene as a master gene for ID element amplification.

Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice.

The human homologue of the retroviral oncogene qin maps to chromosome 14q13.

Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx.

Molecular analysis of antigen-independent adhesion forces between T and B lymphocytes.

An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.

Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.

Recombination between defective tombusvirus RNAs generates functional hybrid genomes.

Id-1 as a possible transcriptional mediator of muscle disuse atrophy.

Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.

A Rev-inducible mutant gag gene stably transferred into T lymphocytes: an approach to gene therapy against human immunodeficiency virus type 1 infection.

Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus.

Selective 5-HT1D alpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development.

A faster-acting and more potent form of tissue plasminogen activator.

De novo design and structural characterization of an alpha-helical hairpin peptide: a model system for the study of protein folding intermediates.

Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary.

Molecular basis of splotch and Waardenburg Pax-3 mutations.

Evidence that an amoeba acquired a chloroplast by retaining part of an engulfed eukaryotic alga.

Mast cells with gonadotropin-releasing hormone-like immunoreactivity in the brain of doves.

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia.

Rapid cell variation can determine the establishment of a persistent viral infection.

The nature of the autoimmune antibody repertoire in human immunodeficiency virus type 1 infection.

Parasite virulence and disease patterns in Plasmodium falciparum malaria.

Mutants of Escherichia coli K-12 that are resistant to a selenium analog of lipoic acid identify unknown genes in lipoate metabolism.

UV photoelectron and ab initio quantum mechanical characterization of valence electrons in Na(+)-water-2'-deoxyguanosine 5'-phosphate clusters: electronic influences on DNA alkylation by methylating and ethylating carcinogens.

Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors.

Discrimination of odortypes determined by the major histocompatibility complex among outbred mice.

Mast cells synthesize, store, and release nerve growth factor.

Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization.

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

Activation of cyclin A-dependent protein kinases during apoptosis.

Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes.

Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice.

Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial and endothelial cells.

Properties of angiotensin II receptors in glial cells from the adult corpus callosum.

Primary structure and functional expression of a guinea pig kappa opioid (dynorphin) receptor.

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Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line.

Diffusivity of myoglobin in intact skeletal muscle cells.

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Redox modulation of the expression of bacterial genes encoding cysteine-rich proteins in plant protoplasts.

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NMR observation of substrate in the binding site of an active sugar-H+ symport protein in native membranes.

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An altered-specificity mutation in a human POU domain demonstrates functional analogy between the POU-specific subdomain and phage lambda repressor.

Peptide nucleic acid.DNA strand displacement loops as artificial transcription promoters.

Growth factor-mediated induction of the delayed early gene T1 depends on a 12-O-tetradecanoylphorbol 13-acetate-responsive element located 3.6 kb upstream of the transcription initiation site.

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Organization of pioneer retinal axons within the optic tract of the rhesus monkey.

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Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A.

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Left hemisphere dominance for processing vocalizations in adult, but not infant, rhesus monkeys: field experiments.

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Erythropoietin receptor mRNA expression in human endothelial cells.

Regulation of apoptosis in transgenic mice by simian virus 40 T antigen-mediated inactivation of p53.

Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src.

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Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists.

Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice.

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Thalidomide is an inhibitor of angiogenesis.

Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake.

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L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

Intracellular pH and the control of multidrug resistance

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Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes.

Content Provider	PubMed Central
Author	Wiseman, R. W. Cochran, C. Dietrich, W. Lander, E. S. Söderkvist, P.
Abstract	To identify the potential involvement of tumor-suppressor gene inactivation during neoplastic development in B6C3F1 mice, genetic losses were determined from allelotypes of butadiene-induced lung and mammary adenocarcinomas. By using length polymorphisms in restriction fragments and simple sequence repeats, or "microsatellites," markers on each autosome were analyzed for allele losses in tumor DNAs. Losses of heterozygosity on chromosome 11 were observed at several loci surrounding the p53 tumor-suppressor gene (Trp53) in 12 of 17 mammary tumors and 2 of 8 lung tumors. Although most of these alterations appeared to result from nondisjunction, at least two examples of somatic recombination or deletion were also observed. Southern analysis revealed a homozygous deletion of the remaining Trp53 allele of one of these mammary tumors. Losses of heterozygosity were also detected at the Rb-1 tumor-suppressor gene in 7 of 17 mammary tumors and 1 lung tumor. Finally, frequent allele losses were observed on chromosome 4 in lung tumors. Analysis of nine chromosome 4 loci defined an interstitial deletion containing the Ifa gene cluster in one of the lung tumors. A tumor-suppressor gene was previously mapped to this region of chromosome 4 in studies with somatic cell hybrids. In addition, homozygous deletions have been reported in a homologous region of human chromosome 9p for acute lymphocytic leukemias, glioblastomas, melanomas, and lung carcinomas. These findings suggest that the inactivation of tumor-suppressor genes including Trp53, Rb-1, and an unidentified gene on chromosome 4 plays a significant role during carcinogenesis in mice.
Starting Page	3759
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	91
Language	English
Publisher Date	1994-04-26
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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