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| Content Provider | PubMed Central |
|---|---|
| Author | Serafine, Katherine M. Bentley, Todd A. Wouter, Koek France, Charles P. |
| Abstract | Eating high fat chow accelerates the development of sensitization to cocaine-induced locomotion in female rats. It is not known whether consumption of sucrose or saccharin also increases sensitivity to the behavioral effects of cocaine or whether continuous (or intermittent) access to these feeding conditions is necessary to change sensitivity. Adolescent female Sprague-Dawley rats were assigned to 1 of 7 feeding conditions from post natal day (PND) 25 through 60. Rats ate either high fat (60% kcal from fat) chow and drank water, or standard (17% kcal from fat) chow and drank either water, 10% sucrose solution, or 0.1% saccharin solution. Rats had either continuous access to high fat chow, sucrose or saccharin or they had intermittent access (i.e. 2 days per week) to these substances with access to water and standard chow on other days. As compared with rats eating standard chow, continuous (but not intermittent) access to high fat chow enhanced the development of sensitization to cocaine-induced (1–17.8 mg/kg) locomotion; drinking sucrose or saccharin (continuous or intermittent access) did not alter the development of sensitization to cocaine-induced locomotion. The impact of feeding condition on behavioral effects of cocaine varies between sexes and across dietary composition. |
| Related Links | http://dx.doi.org/10.1097/fbp.0000000000000114 |
| Ending Page | 325 |
| Page Count | 5 |
| Starting Page | 321 |
| File Format | |
| ISSN | 09558810 |
| e-ISSN | 14735849 |
| Journal | Behavioural pharmacology |
| Issue Number | 3 |
| Volume Number | 26 |
| Language | English |
| Publisher Date | 2015-04-01 |
| Access Restriction | Open |
| Subject Keyword | Pharmacology Psychiatry and Mental health Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Psychiatry and Mental Health |
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