NDLI: Attenuation of Cocaine Induced Locomotor Sensitization in Rats Sustaining Genetic or Pharmacologic Antagonism of Ghrelin Receptors

Please wait, while we are loading the content...

Attenuation of Cocaine Induced Locomotor Sensitization in Rats Sustaining Genetic or Pharmacologic Antagonism of Ghrelin Receptors

Content Provider	PubMed Central
Author	Clifford, P. Shane Rodriguez, Juan Schul, Destri Hughes, Samuel Kniffin, Tracey Hart, Nigel Eitan, Shoshana Wellman, Paul J. Brunel, Luc Fehrentz, Jean-alain Martinez, Jean
Abstract	Systemic infusions of the orexigenic peptide ghrelin (GHR) increase dopamine levels within the nucleus accumbens and augment cocaine stimulated locomotion and conditioned place preference in rats; observations that suggest an important role for ghrelin and GHR receptors (GHR-Rs) in drug reinforcement. In the present studies, we examined the development of cocaine locomotor sensitization in rats sustaining either pharmacologic antagonism or genetic ablation of GHR-Rs. In a pharmacologic study, adult male rats were injected (i.p.) with either 0, 3 or 6 mg/kg JMV 2959 (a GHR-R1 receptor antagonist) and 20 minutes later with either vehicle or 10 mg/kg cocaine HCl on each of 7 consecutive days. Rats pretreated with JMV 2959 showed significantly attenuated cocaine-induced hyperlocomotion. In a second study, adult wild type (WT) or mutant rats sustaining ENU-induced knockout of GHR-R (GHR-R (−/−)) received daily injections (i.p) of vehicle (0.9% saline) or 10.0 mg/kg cocaine HCl for 14 successive days. GHR-R null rats treated repeatedly with cocaine showed diminished development of cocaine locomotor sensitization relative to WT rats treated with cocaine. To verify the lack of GHR-R function in the GHR-R (−/−) rats, a separate feeding experiment was conducted in which WT rats, but not GHR-R (−/−) rats, were noted to eat more after a systemic injection of 15 nmol ghrelin than after vehicle. These results suggest that GHR-R activity is required for the induction of locomotor sensitization to cocaine and complement an emerging literature implicating central GHR systems in drug reward. Ghrelin (GHR) is an orexigenic gut peptide that is transported across the blood brain barrier and interacts with GHR receptors (GHR-R) located on ventral tegmental dopamine neurons.
Related Links	http://dx.doi.org/10.1111/j.1369-1600.2011.00339.x
Ending Page	963
Page Count	8
Starting Page	956
File Format	PDF
ISSN	13556215
e-ISSN	13691600
Journal	Addiction biology
Issue Number	6
Volume Number	17
Language	English
Publisher Date	2012-11-01
Access Restriction	Open
Subject Keyword	Medicine (miscellaneous) Pharmacology Psychiatry and Mental health Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pharmacology Psychiatry and Mental Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Pharmacologic Antagonism of Ghrelin Receptors Attenuates Development of Nicotine Induced Locomotor Sensitization in Rats

Pharmacologic antagonism of ghrelin receptors attenuates development of nicotine induced locomotor sensitization in rats.

Eating high fat chow, but not drinking sucrose or saccharin, enhances the development of sensitization to the locomotor effects of cocaine in adolescent female rats

Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice

Impact of Food Restriction and Cocaine on Locomotion in Ghrelin- and Ghrelin-Receptor Knockout Mice

Mephedrone interactions with cocaine: prior exposure to ‘bath salt’ constituent enhances cocaine-induced locomotor activation in rats

Subregion-specific Role of Glutamate Receptors in the Nucleus Accumbens on Drug Context-induced Reinstatement of Cocaine-seeking Behavior in Rats

Limitations to the Generality of Cocaine Locomotor Sensitization

Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference

Attenuation of Cocaine Induced Locomotor Sensitization in Rats Sustaining Genetic or Pharmacologic Antagonism of Ghrelin Receptors

Similar Documents

Pharmacologic Antagonism of Ghrelin Receptors Attenuates Development of Nicotine Induced Locomotor Sensitization in Rats

Pharmacologic antagonism of ghrelin receptors attenuates development of nicotine induced locomotor sensitization in rats.

Eating high fat chow, but not drinking sucrose or saccharin, enhances the development of sensitization to the locomotor effects of cocaine in adolescent female rats

Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice

Impact of Food Restriction and Cocaine on Locomotion in Ghrelin- and Ghrelin-Receptor Knockout Mice

Mephedrone interactions with cocaine: prior exposure to ‘bath salt’ constituent enhances cocaine-induced locomotor activation in rats

Subregion-specific Role of Glutamate Receptors in the Nucleus Accumbens on Drug Context-induced Reinstatement of Cocaine-seeking Behavior in Rats

Limitations to the Generality of Cocaine Locomotor Sensitization

Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference

Attenuation of Cocaine Induced Locomotor Sensitization in Rats Sustaining Genetic or Pharmacologic Antagonism of Ghrelin Receptors