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| Content Provider | PubMed Central |
|---|---|
| Author | Nolen, Brian M. Lomakin, Aleksey Adele, Marrangoni Velikokhatnaya, Liudmila Prosser, Denise Lokshin, Anna E. |
| Abstract | The early detection of lung cancer has the potential to greatly impact disease burden through the timely identification and treatment of affected individuals at a manageable stage of development. The insufficient specificity demonstrated by currently used screening and diagnostic techniques has led to intense investigation into biomarkers as diagnostic tools. Urine may represent a non-invasive alternative matrix for diagnostic biomarker development. We performed an analysis of 242 biomarkers in urines obtained from 83 NSCLC patients, 74 patients diagnosed with benign pulmonary conditions and 77 healthy donors. A large number of significant alterations were observed between the NSCLC and control groups. A multivariate analysis identified a three biomarker panel consisting of IGFBP-1, sIL-1Ra, CEACAM-1 which discriminated NSCLC from healthy controls with a SN/SP of 84/95 in an initial training set and 72/100 in an independent validation set. This panel performed well among multiple subtypes of NSCLC and early stage disease but demonstrated only limited efficacy for the discrimination of NSCLC from benign controls and limited specificity for several other cancers and tuberculosis patients. These findings demonstrate that urine biomarkers may provide screening and diagnostic properties which exceed those reported for serum biomarkers and approach a level necessary for further clinical development. |
| Related Links | http://dx.doi.org/10.1158/1940-6207.CAPR-14-0210 |
| Ending Page | 119 |
| Page Count | 9 |
| Starting Page | 111 |
| File Format | |
| ISSN | 19406215 |
| e-ISSN | 19406215 |
| Journal | Cancer prevention research (Philadelphia, Pa.) |
| Issue Number | 2 |
| Volume Number | 8 |
| Language | English |
| Publisher Date | 2015-02-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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