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| Content Provider | PubMed Central |
|---|---|
| Author | Wang, Joshua W. Hung, Chein-fu Huh, Warner K. Trimble, Cornelia L. Roden, Richard B. S. |
| Abstract | Persistent infection by one of fifteen high risk human papillomavirus (hrHPV) types is a necessary but not sufficient cause of 5% of all human cancers. This provides a remarkable opportunity for cancer prevention via immunization. Since Harald zur Hausen’s pioneering identification of hrHPV types 16 and 18, found in ~50% and ~20% of cervical cancers respectively, two prophylactic HPV vaccines containing virus-like particles (VLP) of each genotype have been widely licensed. These vaccines are beginning to impact infection and HPV-associated neoplasia rates after immunization campaigns in adolescents. Here we review recent progress and opportunities to better prevent HPV-associated cancers, including: broadening immune-protection to cover all hrHPV types, reducing the cost of HPV vaccines especially for developing countries that have the highest rates of cervical cancer, and immune-based treatment of established HPV infections. Screening based upon George Papanicolaou’s cervical cytology testing, and more recently detection of hrHPV DNA/RNA, followed by ablative treatment of high grade cervical intraepithelial neoplasia (CIN2/3) have substantially reduced cervical cancer rates, and we examine their interplay with immune-based modalities for the prevention and eventual elimination of cervical cancer and other HPV-related malignancies. |
| Related Links | http://dx.doi.org/10.1158/1940-6207.capr-14-0311 |
| Ending Page | 104 |
| Page Count | 10 |
| Starting Page | 95 |
| File Format | |
| ISSN | 19406207 |
| e-ISSN | 19406215 |
| Journal | Cancer prevention research (Philadelphia, Pa.) |
| Issue Number | 2 |
| Volume Number | 8 |
| Language | English |
| Publisher Date | 2015-02-01 |
| Access Restriction | Open |
| Subject Keyword | Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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