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| Content Provider | PubMed Central |
|---|---|
| Author | Xie, Xiaohu Wells, Audrey M. Fuchs, Rita A. |
| Abstract | Despite the well-documented involvement of dopamine D1-like receptor stimulation in cocaine-induced goal-directed behaviors, little is known about the specific contribution of D1-like receptor populations in the dorsal hippocampus (DH) to drug context-induced cocaine-seeking or drug-reinforced instrumental behaviors. To investigate this question, rats were trained to lever press for un-signaled cocaine infusions in a distinct context followed by extinction training in a different context. Cocaine-seeking behavior (non-reinforced lever responding) was then assessed in the previously cocaine-paired and extinction contexts. SCH23390-induced D1-like receptor antagonism in the DH, but not the overlying trunk region of the somatosensory cortex, dose-dependently inhibited drug context-induced cocaine-seeking behavior, without altering cocaine-reinforced instrumental responding, cocaine intake, food-reinforced instrumental responding, or general motor activity, relative to vehicle treatment. These findings suggest that D1-like receptor stimulation in the DH is critical for the incentive motivational effects and/or memory of cocaine-paired contextual stimuli that contribute to drug-seeking behavior. |
| Related Links | http://dx.doi.org/10.1017/s1461145714000340 |
| Ending Page | 1538 |
| Page Count | 6 |
| Starting Page | 1533 |
| File Format | |
| ISSN | 14611457 |
| e-ISSN | 14695111 |
| Journal | The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) |
| Issue Number | 9 |
| Volume Number | 17 |
| Language | English |
| Publisher Date | 2014-09-01 |
| Access Restriction | Open |
| Subject Keyword | Pharmacology (medical) Pharmacology Psychiatry and Mental health Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) Psychiatry and Mental Health |
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