NDLI: Loss of Alternative Non-Drug Reinforcement Induces Relapse of Cocaine-Seeking in Rats: Role of Dopamine D1 Receptors

Content Provider	PubMed Central
Author	Quick, Stacey L. Pyszczynski, Adam D. Colston, Kelli A. Shahan, Timothy A.
Copyright Year	2011
Abstract	Animal models of relapse to drug seeking have focused primarily on relapse induced by exposure to drugs, drug-associated cues or contexts, and foot-shock stress. However, relapse in human drug abusers is often precipitated by loss of alternative non-drug reinforcement. The present experiment used a novel ‘resurgence' paradigm to examine relapse to cocaine seeking of rats as a result of loss of an alternative source of non-drug reinforcement. Rats were first trained to press a lever for intravenous infusions of cocaine. Next, cocaine deliveries were omitted and food pellets were provided for an alternative nose-poke response. Once cocaine seeking was reduced to low levels, food pellets for the alternative response were also omitted. Cocaine seeking increased with the loss of the alternative non-drug reinforcer (ie, resurgence occurred) despite continued extinction conditions. The increase in cocaine seeking did not occur in another group of rats injected with SCH 23390 before the loss of the alternative reinforcer. These results suggest that removal of an alternative source of reinforcement may induce relapse of cocaine seeking and that the dopamine D1 receptor may have a role in this effect.
Related Links	http://dx.doi.org/10.1038/npp.2010.239
Ending Page	1020
Page Count	6
Starting Page	1015
File Format	PDF
ISSN	0893133X
e-ISSN	1740634X
Journal	Neuropsychopharmacology
Issue Number	5
Volume Number	36
Language	English
Publisher	Nature Publishing Group
Publisher Date	2011-04-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pharmacology Psychiatry and Mental Health

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