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| Content Provider | PubMed Central |
|---|---|
| Author | Gesing, Adam Wang, Feiya List, Edward O. Berryman, Darlene E. Masternak, Michal M. Lewinski, Andrzej Karbownik-lewinska, Malgorzata Kopchick, John J. Bartke, Andrzej |
| Copyright Year | 2014 |
| Abstract | Apoptosis is a process that affects life span and health. Mice with liver-specific disruption of the growth hormone receptor (GHR) gene (ie, Ghr gene) liver-specific growth hormone receptor knockout [LiGHRKO] mice), as opposed to mice with global deletion of the Ghr gene (GHRKO; Ghr−/−), are characterized by severe hepatic steatosis and lack of improved insulin sensitivity. We have previously shown that levels of proapoptotic factors are decreased in long-lived and insulin-sensitive GHRKO mice. In the current study, expression of specific apoptosis-related genes was assessed in brains, kidneys, and livers of male and female LiGHRKO and wild-type mice using real-time PCR. In the brain, expression of Caspase 3, Caspase 9, Smac/DIABLO, and p53 was decreased in females compared with males. Renal expression of Caspase 3 and Noxa also decreased in female mice. In the liver, no differences were seen between males and females. Also, no significant genotype effects were detected in the examined organs. Lack of significant genotype effect in kidneys contrasts with previous observations in GHRKO mice. Apparently, global GHR deletion induces beneficial changes in apoptotic factors, whereas liver-specific GHR disruption does not. Furthermore, sexual dimorphism may play an important role in regulating apoptosis during liver-specific suppression of the somatotrophic signaling. |
| Related Links | http://dx.doi.org/10.1093/gerona/glu008 |
| Ending Page | 52 |
| Page Count | 9 |
| Starting Page | 44 |
| File Format | |
| ISSN | 10795006 |
| e-ISSN | 1758535X |
| Journal | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences |
| Issue Number | 1 |
| Volume Number | 70 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2015-01-01 |
| Access Restriction | Open |
| Rights Holder | Oxford University Press |
| Subject Keyword | Ageing Geriatrics and Gerontology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Aging Geriatrics and Gerontology |
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