NDLI: The slow-aging growth hormone receptor/binding protein gene-disrupted (GHR-KO) mouse is protected from aging-resultant neuromusculoskeletal frailty

Content Provider	PubMed Central
Author	Arum, Oge Rickman, Dustin J. Kopchick, John J. Bartke, Andrzej
Abstract	Neuromusculoskeletal (physical) frailty is an aging-attributable biomedical issue of extremely high import, from both public health and individual perspectives. Yet, it is rarely studied in nonhuman research subjects and very rarely studied in animals with extended longevity. In an effort to address this relatively neglected area, we have conducted a longitudinal investigation of the neuromusculoskeletal healthspan in mice with two senescence-slowing interventions: growth hormone (GH) resistance, produced by GH receptor “knockout” (GHR-KO), and caloric restriction (CR). We report marked improvements in the retention of strength, balance, and motor coordination by the longevity-conferring GHR/BP gene disruption, CR regimen, or a combination of the two. Specifically, GHR-KO mice exhibit superior grip strength, balance, and motor coordination at middle age, and CR mice display superior grip strength at middle age. The advantageous effects established by middle-age are more pronounced in old-age, and these robust alterations are, generally, not gender-specific. Thus, we show that genetic and/or dietary interventions that engender longevity are also beneficial for the retention of neuromusculoskeletal health and functionality. The translational knowledge to be gained from subsequent molecular or histological investigations of these models of preserved functionality and decelerated senescence is potentially relevant to the efforts to reduce the specter of fear, falls, fracture, and frailty in the elderly.
Related Links	http://dx.doi.org/10.1007/s11357-013-9551-x
Ending Page	127
Page Count	11
Starting Page	117
File Format	PDF
ISSN	01619152
e-ISSN	15744647
Journal	Age
Issue Number	1
Volume Number	36
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-02-01
Access Restriction	Open
Rights Holder	Springer Netherlands
Subject Keyword	Ageing Geriatrics and Gerontology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Aging Geriatrics and Gerontology

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