NDLI: Diabetes increases pancreatitis induced systemic inflammation but has little effect on inflammation and cell death in the lung

Content Provider	PubMed Central
Author	Zechner, Dietmar Spitzner, Marie Müller-graff, Tassilo Vollmar, Brigitte
Copyright Year	2014
Abstract	Acute pancreatitis (AP) can lead to a systemic inflammatory response that often results in acute lung injury and single or multiple organ failure. In a previous study we demonstrated that diabetes aggravates the local pathophysiological process during AP. In this study we explore, if diabetes also increases pancreatitis induced systemic inflammation and causes lung injury. Acute pancreatitis was induced in untreated and streptozotocin-treated diabetic mice by injection of cerulein. Systemic inflammation was studied by IL-6 ELISA in blood plasma and white blood cell count. Lung inflammation and lung injury were quantified by chloroacetate esterase staining, evaluation of the alveolar cellularity index and cleaved caspase-3 immunohistochemistry. In normoglycaemic mice AP increased the IL-6 concentration in plasma and caused lymphocytopenia. Diabetes significantly increased the IL-6 concentration in plasma and further reduced the number of lymphocytes during AP, whereas diabetes had little effect on these parameters in the absence of pancreatitis. However, diabetes only marginally increased lung inflammation and did not lead to cell death of the lung epithelium during AP. We conclude that diabetes increases parameters of systemic inflammation during AP, but that this increase is insufficient to cause lung injury.
Related Links	http://dx.doi.org/10.1111/iep.12103
Ending Page	417
Page Count	7
Starting Page	411
File Format	PDF
ISSN	09599673
e-ISSN	13652613
Journal	International Journal of Experimental Pathology
Issue Number	6
Volume Number	95
Language	English
Publisher	BlackWell Publishing Ltd
Publisher Date	2014-12-01
Access Restriction	Open
Rights Holder	BlackWell Publishing Ltd
Subject Keyword	Pathology and Forensic Medicine Cell Biology Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Pathology and Forensic Medicine

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